伐地那非

伐地那非用途

Vardenafil, also known as BAY 38-9456, is a PDE5 inhibitor used for treating erectile dysfunction. Vardenafil's indications and contra-indications are the same as with other PDE5 inhibitors; it is closely related in function to sildenafil citrate (Viagra) and tadalafil (Cialis). The difference between the vardenafil molecule and sildenafil citrate is a nitrogen atom's position and the change of sildenafil's piperazine ring methyl group to an ethyl group. Tadalafil is structurally different from both sildenafil and vardenafil. Vardenafil's relatively short effective time is comparable to but somewhat longer than sildenafil's.

伐地那非名称

[ CAS 号 ]:
224789-15-5

[ 中文名 ]:
瓦地那非二盐酸盐

[ 英文名 ]:
Vardenafil dihydrochloride

[中文别名 ]:

[英文别名 ]:

MFCD06797950
Vardenafil dihydrochloride
EINECS 200-659-6

伐地那非物理化学性质

[ 沸点 ]:
692.2ºC at 760mmHg

[ 熔点 ]:
214-216°C

[ 分子式 ]:
C₂₃H₃₄Cl₂N₆O₄S

[ 分子量 ]:
561.525

[ 闪点 ]:
372.5ºC

[ 精确质量 ]:
560.173950

[ PSA ]:
253.41000

[ LogP ]:
1.77850

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
5.17E-19mmHg at 25°C

[ 储存条件 ]:
Refrigerator

伐地那非MSDS

详细MSDS(安全技术说明书)

伐地那非安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 危害码 (欧洲) ]:
F,T

[ 风险声明 (欧洲) ]:
11-23/24/25-39/23/24/25

[ 安全声明 (欧洲) ]:
7-16-36/37-45

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution

伐地那非文献

Improvement of exercise capacity in monocrotaline-induced pulmonary hypertension by the phosphodiesterase-5 inhibitor Vardenafil.

Respir. Physiol. Neurobiol. 186(1) , 61-4, (2013)

Vardenafil, a phosphodiesterase-5 inhibitor, is approved for the therapy of erectile dysfunction. However, in contrast to Sildenafil and Tadalafil, little is known about its effects on pulmonary hyper...

SOP conservative (medical and mechanical) treatment of erectile dysfunction.

J. Sex. Med. 10(1) , 130-71, (2013)

Erectile dysfunction (ED) is the most frequently treated male sexual dysfunction worldwide. ED is a chronic condition that exerts a negative impact on male self-esteem and nearly all life domains incl...

High inter-individual variability of vardenafil pharmacokinetics in patients with pulmonary hypertension.

Eur. J. Clin. Pharmacol. 69(2) , 197-207, (2013)

To evaluate the pharmacokinetic parameters of a single oral dose of vardenafil in patients with pulmonary hypertension (PH).Sixteen patients with PH received vardenafil in single oral doses (20, 10 or...

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