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羟钴胺素乙酸盐

羟钴胺素乙酸盐用途

Hydroxocobalamin acetate 是一种可注射的天然维生素 B12,具有良好的不良反应特征,可作为治疗维生素 B12 缺乏症(包括恶性贫血)的膳食补充剂。

羟钴胺素乙酸盐名称

[ CAS 号 ]:
22465-48-1

[ 中文名 ]:
羟钴胺醋酸盐

[ 英文名 ]:
Hydroxocobalamin Acetate

[英文别名 ]:

Hydroxocobalamin acetate
Vitamin B12a acetate
HYDROXOCOBALAMIN ACETATE

羟钴胺素乙酸盐生物活性

[ 描述 ]:

Hydroxocobalamin acetate 是一种可注射的天然维生素 B12,具有良好的不良反应特征,可作为治疗维生素 B12 缺乏症(包括恶性贫血)的膳食补充剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[ 靶点 ]

The cobalt atom of hydroxocobalamin binds cyanide and nitric oxide (NO) and hydroxocobalamin attenuates vascular responses to NO in vitro[3].

[参考文献]

[1]. Cheungpasitporn W, et al. High-dose hydroxocobalamin for vasoplegic syndrome causing false blood leak alarm. Clin Kidney J. 2017 Jun;10(3):357-362.

[2]. Wang H, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2018 Mar 15;3:CD004655.

[3]. Greenberg SS, et al. Hydroxocobalamin (vitamin B12a) prevents and reverses endotoxin-induced hypotension and mortality in rodents: role of nitric oxide. J Pharmacol Exp Ther. 1995 Apr;273(1):257-65.

羟钴胺素乙酸盐物理化学性质

[ 熔点 ]:
>300ºC.

[ 分子式 ]:
C₆₄H₉₁CoN₁₃O₁₆P

[ 分子量 ]:
1388.39000

[ 精确质量 ]:
1387.58000

[ PSA ]:
490.17000

[ LogP ]:
6.62930

[ 外观性状 ]:
固体;Orange to Brown to Dark red powder to crystal

[ 储存条件 ]:
0-10°C;存放于惰性气体之中;避免空气,加热

[ 水溶解性 ]:
水溶性：完全溶解；极微溶：乙醇；不溶：乙醚

羟钴胺素乙酸盐MSDS

详细MSDS(安全技术说明书)

羟钴胺素乙酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GG3740000

CHEMICAL NAME :: Cobinamide, acetate (salt) hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole

CAS REGISTRY NUMBER :: 22465-48-1

LAST UPDATED :: 199409

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C64-H91-Co-N13-O16-P

MOLECULAR WEIGHT :: 1388.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,622,1982

羟钴胺素乙酸盐安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H351

[ 警示性声明 ]:
P280

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
GG3740000

羟钴胺素乙酸盐文献

Processing of alkylcobalamins in mammalian cells: A role for the MMACHC (cblC) gene product.

Mol. Genet. Metab. 97 , 260-266, (2009)

The MMACHC gene product of the cblC complementation group, referred to as the cblC protein, catalyzes the in vitro and in vivo decyanation of cyanocobalamin (vitamin B(12)). We hypothesized that the c...

Vitamin B12-derivatives-enzyme cofactors and ligands of proteins and nucleic acids.

Chem. Soc. Rev. 40 , 4346-4363, (2011)

B(12)-cofactors play important roles in the metabolism of microorganisms, animals and humans. Microorganisms are the only natural sources of B(12)-derivatives, and the latter are "vitamins" for other ...

B12 trafficking in mammals: A for coenzyme escort service.

ACS Chem. Biol. 1 , 149-159, (2006)

Many coenzymes are vitamins that are assimilated in mammals into their active form from precursors obtained from the diet. They are often both rare and reactive rendering the likelihood low that the c...

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