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6-巯基嘌呤-2-脱氧核苷

6-巯基嘌呤-2-脱氧核苷用途

2′-脱氧-6-硫鸟苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

6-巯基嘌呤-2-脱氧核苷名称

[ CAS 号 ]:
2239-64-7

[ 中文名 ]:
6-巯基嘌呤-2-脱氧核苷

[ 英文名 ]:
6-mercaptopurine-2'-deoxyriboside

[中文别名 ]:

6-巯基嘌呤-2'-脱氧核苷

[英文别名 ]:

6-MERCAPTOPURINE-2'-DEOXYRIBONUCLEOSIDE
6-Mercaptopurine-2'-deoxyriboside
6-thio-2'-deoxyinosine
MFCD00056001
6-Mercapto-9-(2'-deoxy-b-D-ribofuranosyl)purine

6-巯基嘌呤-2-脱氧核苷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

[参考文献]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

6-巯基嘌呤-2-脱氧核苷物理化学性质

[ 密度 ]:
1.87g/cm3

[ 沸点 ]:
665.9ºC at 760mmHg

[ 分子式 ]:
C₁₀H₁₂N₄O₃S

[ 分子量 ]:
268.29

[ 闪点 ]:
356.5ºC

[ 精确质量 ]:
268.06300

[ PSA ]:
128.28000

[ LogP ]:
0.12960

[ 蒸汽压 ]:
1.23E-18mmHg at 25°C

[ 折射率 ]:
1.863

[ 储存条件 ]:
−20°C

6-巯基嘌呤-2-脱氧核苷MSDS

详细MSDS(安全技术说明书)

6-巯基嘌呤-2-脱氧核苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UP0762000

CHEMICAL NAME :: 9H-Purine-6(1H)-thione, 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-

CAS REGISTRY NUMBER :: 2239-64-7

LAST UPDATED :: 199206

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H12-N4-O3-S

MOLECULAR WEIGHT :: 268.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TDKNAF Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. (Osaka, Japan) V.1-28, 1936-69. For publisher information, see TAKHAA. Volume(issue)/page/year: 27,1,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TDKNAF Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. (Osaka, Japan) V.1-28, 1936-69. For publisher information, see TAKHAA. Volume(issue)/page/year: 27,1,1968

6-巯基嘌呤-2-脱氧核苷安全信息

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
22

[ 安全声明 (欧洲) ]:
36

[ WGK德国 ]:
3

[ RTECS号 ]:
UP0762000

6-巯基嘌呤-2-脱氧核苷上下游产品

6-巯基嘌呤-2-脱氧核苷上游产品

6-巯基嘌呤-2-脱氧核苷下游产品

6-巯基嘌呤-2-脱氧核苷文献

Nucleosides of azathioprine and thiamiprine as antiarthritics.

J. Med. Chem. 32 , 1471-1475, (1989)

Azathioprine [Imuran; 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine] is a widely used immunosuppressive and antiarthritic drug. For the sake of comparison, the riboside, the 2'-deoxyriboside, ...

Synthetic nucleosides and nucleotides. XIV. Facile synthesis and antitumor activities of 6-mercaptopurine 2'-deoxyriboside and related compounds.

J. Pharmacobiodyn. 3 , 105-110, (1980)

Convenient synthesis of oligodeoxynucleotides containing 2'-deoxy-6-thioinosine.

Nucleosides Nucleotides Nucleic Acids 22 , 635-639, (2003)

A facile synthesis of oligodeoxynucleotides (ODN) containing 2'-deoxy-6-thioinosine (dI6S) based on the convertible nucleoside O6-phenyl-2'-deoxyinosine is presented. After standard solid-phase DNA sy...

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