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苏达灭

苏达灭用途

6-Hydroxymelatonin 是褪黑素 (Melatonin) 通过 CYP1A2 代谢的主要代谢物。

苏达灭名称

[ CAS 号 ]:
2208-41-5

[ 中文名 ]:
苏达灭

[ 英文名 ]:
6-Hydroxymelatonin

[中文别名 ]:

[英文别名 ]:

6-HydroxyMelatonin
6-Hydroxy Melatonin

苏达灭生物活性

[ 描述 ]:

6-Hydroxymelatonin 是褪黑素 (Melatonin) 通过 CYP1A2 代谢的主要代谢物。

[ 相关类别 ]:

研究领域 >> 代谢疾病

研究领域 >> 神经疾病

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Härtter S, et al. Orally given melatonin may serve as a probe drug for cytochrome P450 1A2 activity in vivo: a pilot study. Clin Pharmacol Ther. 2001 Jul;70(1):10-6.

[相关活性小分子]

苏达灭物理化学性质

[ 密度 ]:
1.266g/cm3

[ 沸点 ]:
564.7ºC at 760mmHg

[ 熔点 ]:
172-175ºC

[ 分子式 ]:
C₁₃H₁₆N₂O₃

[ 分子量 ]:
248.27800

[ 闪点 ]:
295.3ºC

[ 精确质量 ]:
248.11600

[ PSA ]:
74.35000

[ LogP ]:
1.95160

[ 蒸汽压 ]:
2.35E-13mmHg at 25°C

[ 折射率 ]:
1.627

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
alcohol: soluble

苏达灭毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC3607000

CHEMICAL NAME :: Acetamide, N-(2-(6-hydroxy-5-methoxyindol-3-yl)ethyl)-

CAS REGISTRY NUMBER :: 2208-41-5

BEILSTEIN REFERENCE NO. :: 0483231

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C13-H16-N2-O3

MOLECULAR WEIGHT :: 248.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 8 mg/kg

SEX/DURATION :: male 20 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 33,618,1985

苏达灭安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H351

[ 警示性声明 ]:
P281

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
22-40

[ 安全声明 (欧洲) ]:
36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AC3607000

[ 海关编码 ]:
2933990090

苏达灭合成路线

详细合成路线

苏达灭制备

在叔胺存在下，乙硫醇与光气作用制得乙硫基甲酰氯，再与二异丁胺作用合成丁草特。

苏达灭海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

苏达灭文献

Melatonin and its metabolites accumulate in the human epidermis in vivo and inhibit proliferation and tyrosinase activity in epidermal melanocytes in vitro.

Mol. Cell. Endocrinol. 404 , 1-8, (2015)

Melatonin and its metabolites including 6-hydroxymelatonin (6(OH)M), N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) and 5-methoxytryptamine (5MT) are endogenously produced in human epidermis. This...

Predominance of 2-hydroxymelatonin over melatonin in plants.

J. Pineal Res. 59 , 448-54, (2015)

The cloning of the gene encoding melatonin 2-hydroxylase (M2H), which is responsible for the synthesis of 2-hydroxymelatonin, has expanded the study of melatonin metabolism in plants. Kinetic analysis...

Molecular cloning of melatonin 2-hydroxylase responsible for 2-hydroxymelatonin production in rice (Oryza sativa).

J. Pineal Res. 58(3) , 343-51, (2015)

Although melatonin biosynthetic genes from plants have been cloned, the melatonin catabolism mechanisms remain unclear. To clone the genes responsible for melatonin metabolism, we ectopically expresse...

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苏达灭