氢氧化铝

氢氧化铝用途

Aluminum Hydroxide 是铝佐剂的一种主要形式。基于 Aluminum Hydroxide 辅助的研究包括储存库效应、促吞噬作用和激活促炎症的 NLRP3 通路。Aluminum Hydroxide 还作为佐剂补偿亚单位疫苗的低固有免疫原性。

氢氧化铝名称

[ CAS 号 ]:
21645-51-2

[ 中文名 ]:
氢氧化铝

[ 英文名 ]:
Aluminium hydroxide

[英文别名 ]:

Aluminium hydroxide
ALUMINUM HYDROXIDE
Aluminum trihydroxide
Aluminium trihydroxide
aluminium(III) hydroxide
EINECS 244-492-7
MFCD00003420

氢氧化铝生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. He P, et al. Advances in aluminum hydroxide-based adjuvant research and its mechanism. Hum Vaccin Immunother. 2015;11(2):477-88.

[2]. Amini Y, et al. Aluminum hydroxide nanoparticles show strong activity to stimulate Th-1 immune response against tuberculosis. Artif Cells Nanomed Biotechnol. 2017 Nov;45(7):1331-1335.

氢氧化铝物理化学性质

[ 密度 ]:
2.40

[ 熔点 ]:
300℃

[ 分子式 ]:
Al(OH)₃

[ 分子量 ]:
78.004

[ 精确质量 ]:
77.989754

[ PSA ]:
60.69000

[ 外观性状 ]:
白色非晶形的粉末

[ 储存条件 ]:
库房通风低温干燥

[ 稳定性 ]:
Stable. Incompatible with strong bases.

[ 水溶解性 ]:
insoluble

氢氧化铝MSDS

详细MSDS(安全技术说明书)

氢氧化铝毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BD0940000

CHEMICAL NAME :: Aluminum hydroxide (Al(OH)3)

CAS REGISTRY NUMBER :: 21645-51-2

LAST UPDATED :: 199712

DATA ITEMS CITED :: 26

MOLECULAR FORMULA :: Al-H3-O3

MOLECULAR WEIGHT :: 78.01

WISWESSER LINE NOTATION :: .AL..H3.O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 79 gm/kg/2Y-I

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Musculoskeletal - osteomalacia

REFERENCE :: PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034, Evanston, IL 60204) V.1- 1948- Volume(issue)/page/year: 71,56,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 122 gm/kg/4D

TOXIC EFFECTS :: Gastrointestinal - other changes Nutritional and Gross Metabolic - body temperature increase

REFERENCE :: JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 92,592,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - infant

DOSE/DURATION :: 39 gm/kg/24D-I

TOXIC EFFECTS :: Musculoskeletal - osteomalacia

REFERENCE :: NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 310,1079,1984

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,564,1972 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8040 mg/kg/67D-C

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in phosphorus

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 10,616,1988 *** REVIEWS *** ACGIH TLV-TWA 2 mg(Al)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 2 mg(Al)/m3 JAN 1993 OEL-BELGIUM:TWA 2 mg(Al)/m3 JAN 1993 OEL-DENMARK:TWA 2 mg(Al)/m3 JAN 1993 OEL-FRANCE:TWA 2 mg(Al)/m3 JAN 1993 OEL-GERMANY:TWA 6 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 2 mg(Al)/m3 JAN 1993 OEL-RUSSIA:STEL 6 mg/m3 JAN 1993 OEL-RUSSIA:TWA 2 mg(Al)/m3 JAN 1993 OEL-SWEDEN:TWA 2 mg(Al)/m3 JAN 1993 OEL-SWITZERLAND:TWA 2 mg(Al)/m3 JAN 1993 OEL-SWITZERLAND:TWA 6 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 2 mg(Al)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80390 No. of Facilities: 4981 (estimated) No. of Industries: 85 No. of Occupations: 74 No. of Employees: 97261 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4445 No. of Facilities: 297 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 37773 (estimated) No. of Female Employees: 33522 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9931 No. of Facilities: 59 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 7006 (estimated) No. of Female Employees: 6697 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80390 No. of Facilities: 12057 (estimated) No. of Industries: 123 No. of Occupations: 121 No. of Employees: 325788 (estimated) No. of Female Employees: 84539 (estimated)

氢氧化铝安全信息

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
BD0940000

[ 海关编码 ]:
2818300000

氢氧化铝制备

1.在硫酸铝溶液中，在搅拌下添加碱溶液，生成沉淀经洗涤、过滤、低温干燥后，经粉碎制得成品。也可将脱水后的糊状物直接作为产品。制备中溶液的浓度、温度、反应温度控制，干燥温度等影响产品质量。

2.将硫酸和铝粉或铝灰作用生成硫酸铝，再与碳酸氢铵进行复分解反应，制得氢氧化铝。或者以铝酸钠溶液与硫酸铝溶液中和至pH6.5，生成氢氧化铝沉淀，经水洗、压滤，于70～80℃下干燥，再经粉碎，制得氢氧化铝。其反应式：

3.水铝氧有：(1)在40～60℃，pH>12的条件下，向铝酸钠水溶液吹入二氧化碳；铝酸钠水溶液里不加或添加水铝氧晶种在常温下放置； (2)Al(OC2H5)3和1%～20%乙醇胺NH2C2H4OH共存，于20～60℃水解，将生成的凝胶熟化几个月等方法。

三羟铝石有：(1)在常温下向铝酸钠水溶液吹入二氧化碳；(2)铝汞齐在常温下水解；(3)Al(OC2H5)3在70℃以下水解；(4)氯化铝水溶液用碱金属氢氧化物或氨中和的方法等。

一水软铝石有在氢氧化铝水溶液或弱碱性水溶液中，在150～300℃下对氢氧化铝进行

水热处理；铝汞齐用沸腾水氧化等方法。

水铝石它的稳定区域为275～425℃，水蒸气压在140atm(1atm=98.066kPa)以上。据报道，对氢氧化铝进行水热处理，对水铝氧真空脱水生成的ρ氧化铝及χ氧化铝进行水热处理等均可得到水铝石。

氢氧化铝海关

[ 海关编码 ]: 2818300000

氢氧化铝文献

Tailoring subunit vaccine immunity with adjuvant combinations and delivery routes using the Middle East respiratory coronavirus (MERS-CoV) receptor-binding domain as an antigen.

PLoS ONE 9(11) , e112602, (2014)

The development of an effective vaccine is critical for prevention of a Middle East respiratory syndrome coronavirus (MERS-CoV) pandemic. Some studies have indicated the receptor-binding domain (RBD) ...

Targeting antigens through blood dendritic cell antigen 2 on plasmacytoid dendritic cells promotes immunologic tolerance.

J. Immunol. 192(12) , 5789-801, (2014)

The C-type lectin receptor blood dendritic cell Ag 2 (BDCA2) is expressed exclusively on human plasmacytoid DCs (pDCs) and plays a role in Ag capture, internalization, and presentation to T cells. We ...

Hydrotalcite composites for an effective fluoride buccal administration: a new technological approach.

Int. J. Pharm. 454(1) , 259-68, (2013)

The aim of this work was to develop new mucoadhesive buccal patches containing an inorganic fluorinated compound, MgAl-F, intended for decay prevention. Firstly MgAl-F was synthesized and characterize...

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