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氟米松

氟米松用途

Flumethasone是一种皮质类固醇,是一种局部用药,与Clioquinol联用治疗外耳炎和耳真菌病, Flumethasone作用于动物模型时, 抗炎活性比Cortisone高420倍。

氟米松名称

[ CAS 号 ]:
2135-17-3

[ 中文名 ]:
氟米松

[ 英文名 ]:
Flumethasone

[中文别名 ]:

[英文别名 ]:

6a-Fluorodexamethasone
6α-Fluorodexamethasone
6α,9α-Difluoro-16α-methylprednisolone
Aniprime
Flumethasone
Fluvet
EINECS 218-370-9
flumetasone
Flucorticin
Anaprime

氟米松生物活性

[ 描述 ]:

Flumethasone是一种皮质类固醇,是一种局部用药,与Clioquinol联用治疗外耳炎和耳真菌病, Flumethasone作用于动物模型时, 抗炎活性比Cortisone高420倍。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[相关活性小分子]

氟米松物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
569.8±50.0 °C at 760 mmHg

[ 熔点 ]:
237-240ºC

[ 分子式 ]:
C₂₂H₂₈F₂O₅

[ 分子量 ]:
410.452

[ 闪点 ]:
298.4±30.1 °C

[ 精确质量 ]:
410.190491

[ PSA ]:
94.83000

[ LogP ]:
1.61

[ 蒸汽压 ]:
0.0±3.6 mmHg at 25°C

[ 折射率 ]:
1.579

[ 储存条件 ]:
2-8°C

氟米松毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU3832000

CHEMICAL NAME :: Pregna-1,4-diene-3,20-dione, 6-alpha,9-difluoro-11-beta,17,21-trihydroxy-16-alpha- methyl-

CAS REGISTRY NUMBER :: 2135-17-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C22-H28-F2-O5

MOLECULAR WEIGHT :: 410.50

WISWESSER LINE NOTATION :: L E5 B666 OV AHTTT&J A1 BF CQ E1 FV1 FQ G1 LF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 20 ug/kg

SEX/DURATION :: female 38 week(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 28,407,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 30 ug/kg

SEX/DURATION :: female 31 week(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

REFERENCE :: JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915- Volume(issue)/page/year: 160,867,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 20 ug/kg

SEX/DURATION :: female 40 week(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition

REFERENCE :: THGNBO Theriogenology. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1974- Volume(issue)/page/year: 20,267,1983

氟米松安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H351

[ 警示性声明 ]:
P281

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R40

[ 安全声明 (欧洲) ]:
S22-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TU3832000

[ 海关编码 ]:
2937229000

氟米松合成路线

详细合成路线

氟米松上下游产品

氟米松上游产品

氟米松下游产品

氟米松海关

[ 海关编码 ]: 2937229000

氟米松文献

Veterinary drug residues in domestic and imported foods of animal origin in the Republic of Korea.

Food. Addit. Contam. Part. B. Surveill. 8 , 106-12, (2015)

The Korean National Residue Programme comprises three different approaches for evaluating domestic and imported foods of animal origin: monitoring, surveillance/enforcement and an exploratory test pro...

Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation.

Int. J. Pharm. 370(1-2) , 181-6, (2009)

Charged drug delivery systems are interesting candidates for the delivery of drugs through skin. In the present study, it was possible to create negatively and positively charged oil/water nanoemulsio...

Tympanoplasty graft preparation using ear drops containing polyethylene glycol, flumethasone and clioquinol.

J. Laryngol. Otol. 125(8) , 853-5, (2011)

The aim of tympanoplasty graft preparation is to stiffen the fascia or perichondrium and thereby to optimise ease of manipulation. We report 39 cases utilising a novel technique in which the graft is ...

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氟米松