布拉叶斯

布拉叶斯用途

Blasticidin S 是从 Streptomyces griseochromogenes 中分离的核苷抗生素。Blasticidin S 抑制原核细胞和真核细胞中蛋白质合成。

布拉叶斯名称

[ CAS 号 ]:
2079-00-7

[ 中文名 ]:
灰瘟素

[ 英文名 ]:
Blasticidin S

[中文别名 ]:

[英文别名 ]:

BLASTICIDIN S
bcs-3
blasticidin-S
Blaes
bab
babs
Blas
cytovirin
blasticidin
blastizidin

布拉叶斯生物活性

[ 描述 ]:

Blasticidin S 是从 Streptomyces griseochromogenes 中分离的核苷抗生素。Blasticidin S 抑制原核细胞和真核细胞中蛋白质合成。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[ 靶点 ]

Antibiotic[1]

[体外研究]

杀稻瘟素S(BlaS)是一种广谱抗生素,可抑制原核生物,真菌,植物和哺乳动物细胞的细胞生长[1]。

[参考文献]

[1]. Kitamura K, et al. Critical role of the proton-dependent oligopeptide transporter (POT) in the cellular uptake of the peptidyl nucleoside antibiotic, blasticidin S. Biochim Biophys Acta Mol Cell Res. 2017 Feb;1864(2):393-398.

布拉叶斯物理化学性质

[ 密度 ]:
1.61 g/cm3

[ 沸点 ]:
539.06°C (rough estimate)

[ 熔点 ]:
235-236ºC

[ 分子式 ]:
C₁₇H₂₆N₈O₅

[ 分子量 ]:
422.43900

[ 精确质量 ]:
422.20300

[ PSA ]:
215.67000

[ LogP ]:
0.25370

[ 外观性状 ]:
无色针状

[ 折射率 ]:
1.707

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

布拉叶斯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EC4900000

CHEMICAL NAME :: Blasticidin S

CAS REGISTRY NUMBER :: 2079-00-7

LAST UPDATED :: 199312

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C17-H26-N8-O5

MOLECULAR WEIGHT :: 422.51

WISWESSER LINE NOTATION :: T6O CUTJ EMV1YZ2N1&YZUM FVQ B- AT6NVNJ DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,48,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969 Volume(issue)/page/year: 5,27,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 38 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 30,1022,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969 Volume(issue)/page/year: 5,27,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: QJDRAZ Quarterly Journal of Crude Drug Research. (Lisse, Netherlands) V.1-19, 1961-81. For publisher information, see IJCREE. Volume(issue)/page/year: 8,1274,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2820 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 11,1,1958

布拉叶斯安全信息

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
R28

[ 安全声明 (欧洲) ]:
S45;S24/25;S36/S37

[ 危险品运输编码 ]:
UN 3172

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
29349990

布拉叶斯合成路线

详细合成路线

布拉叶斯上下游产品

布拉叶斯上游产品

布拉叶斯下游产品

布拉叶斯制备

本品是由灰色产色链霉菌的代谢产物中分离出来的抗生素，成品为苄基氨基苯磺酸盐。其生产过程主要是菌种培养后再经发酵、过滤、干燥，最后进行球磨并加以填料而制得成品。

试管斜面孢子28℃培养7～10天，0～4℃冷藏，得茄型瓶孢子；28℃培养7～10天，得一级种子；28℃、48h、空气流量1∶0.3，一瓶孢子接一个种子罐，可得二级种子；然后再在30℃、空气流量1∶0.5、接种子量10%，培养48h，进行三级发酵；再经32℃、空气流量1∶0.8,接种量10%，培养6～7天，出罐。发酵液加盐酸调pH值2，然后进行板框过滤，滤液进行结晶，再加入3倍灭瘟素质量的前体，结晶温度10℃以下，pH值6.1～6
灭瘟素是一种放线菌的代谢产物中分离出来的抗菌素，是一种化学结构很复杂的碱。生产过程从菌种培养经发酵、过滤、干燥后球磨加填料制得。