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3,3'-二甲氧基联苯胺盐酸盐

3,3'-二甲氧基联苯胺盐酸盐用途

【用途一】
主要用作偶氮染料中间体，如制直接蓝RG、直接蓝5B、湖蓝6B等染料，还可用于检测金、铜、钴和钒等元素
【用途二】
主要用于制造蓝色偶氮染料,如直接湖蓝6B、活性深蓝KD-7G。还被用来鉴定金、铜、钴和钒等元素。

3,3'-二甲氧基联苯胺盐酸盐名称

[ CAS 号 ]:
20325-40-0

[ 中文名 ]:
3,3'-二甲氧基联苯胺盐酸盐

[ 英文名 ]:
3,3'-Dimethoxybenzidine dihydrochloride

[中文别名 ]:

[英文别名 ]:

3,3'-Dimethoxybenzidine dihydrochloride
MFCD00012488
3,3′-Dimethoxybenzidine dihydrochloride
DMB DIHYDROCHLORIDE
o-Dianisidinehydrochloride
O-DIANISIDINE REAGENT
BLUE BN BASE DIHYDROCHLORIDE
2-Dianisidine dihydrochloride
EINECS 243-737-5
3,3‘-Dimethoxybenzidine dihydrochloride

3,3'-二甲氧基联苯胺盐酸盐生物活性

[ 描述 ]:

o-Dianisidine盐酸盐是一个比色过氧化物酶底物, 适用于ELISA。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

生化试剂

研究领域 >> 其他

[参考文献]

[1]. Iskra M et al. Copper and zinc concentrations and the activities of ceruloplasmin and superoxide dismutase inatherosclerosis obliterans. Biol Trace Elem Res. 2000 Jan;73(1):55-65.

[2]. Dungchai W et al. Use of multiple colorimetric indicators for paper-based microfluidic devices. Anal Chim Acta. 2010 Aug 3;674(2):227-33.

[相关活性小分子]

3,3'-二甲氧基联苯胺盐酸盐物理化学性质

[ 沸点 ]:
391.3ºC at 760 mmHg

[ 熔点 ]:
268 °C

[ 分子式 ]:
C₁₄H₁₈Cl₂N₂O₂

[ 分子量 ]:
317.211

[ 闪点 ]:
206℃

[ 精确质量 ]:
316.074524

[ PSA ]:
70.50000

[ LogP ]:
5.30160

[ 外观性状 ]:
灰白色粉末

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 水溶解性 ]:
1-5 g/100 mL at 20 ºC

3,3'-二甲氧基联苯胺盐酸盐MSDS

详细MSDS(安全技术说明书)

3,3'-二甲氧基联苯胺盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD1050000

CHEMICAL NAME :: Benzidine, 3,3'-dimethoxy-, dihydrochloride

CAS REGISTRY NUMBER :: 20325-40-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C14-H16-N2-O2.2Cl-H

MOLECULAR WEIGHT :: 317.24

WISWESSER LINE NOTATION :: 1OR BZ ER DZ CO1 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9100 mg/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8271 mg/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9009 mg/kg/39W-C

TOXIC EFFECTS :: Blood - other changes Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1040 mg/kg/1Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Reproductive - Tumorigenic effects - testicular tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5760 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1152 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Reproductive - Tumorigenic effects - uterine tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11 gm/kg/51W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6497 mg/kg/91W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-372,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO o-DIANISIDINE-BASED DYES-air:CA lowest feasible conc. REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7012 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 489 (estimated) No. of Female Employees: 300 (estimated)

3,3'-二甲氧基联苯胺盐酸盐安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H350

[ 警示性声明 ]:
P201-P308 + P313

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R22;R45

[ 安全声明 (欧洲) ]:
S53-S45

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
3

[ RTECS号 ]:
DD1050000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
2923900090

3,3'-二甲氧基联苯胺盐酸盐上下游产品

3,3'-二甲氧基联苯胺盐酸盐上游产品

3,3'-二甲氧基联苯胺盐酸盐下游产品

3,3'-二甲氧基联苯胺盐酸盐制备

主要采用锌粉还原法。以邻硝基苯甲醚为原料，在碱性介质中，用锌粉还原为2,2’-二甲氧基对称二苯肼，再在酸性介质中转位成联大茴香胺硫酸盐，最后用食盐盐析而得。在反应釜中，加入234kg邻硝基苯甲醚，搅拌下加入50%的液碱2L。加热至65ºC，分小批交替加入液碱185kg，温度控制在74~80ºC。加毕，于80~85ºC保温1.5h，加入130L水，搅拌15min。于80~85ºC分批加入105kg锌粉和180L水，直至淡柠檬色结晶出现，保温0.5h。加入400L，降温至35ºC，经180目筛分离去氧化锌，得2,2’-二甲氧基对称二苯肼。

在转位斧中加入碎冰700kg，浓硫酸360kg，于45~60min内，在0~6ºC加入上述二甲氧基对称二苯肼，保持4h。调整酸度在180~200g/L，待物料自行升温至室温，保持18h。于1h内升温至40~45ºC，保持2h。再于1h内升温至60~65ºC，保持1h。加水约1000L，在2h内升温至95ºC。于93~97ºC在1.5h内均匀加盐750kg。加毕，自行降温至60ºC，再冷却至40ºC，过滤。滤饼用600L饱和食盐水洗涤，得3,3’-二甲氧基联苯胺盐酸盐145kg左右。

3,3'-二甲氧基联苯胺盐酸盐海关

[ 海关编码 ]: 2923900090

[ 中文概述 ]:
2923900090 其他季铵盐及季铵碱。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

3,3'-二甲氧基联苯胺盐酸盐文献

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