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3,3'-二甲基联苯胺盐酸盐

3,3'-二甲基联苯胺盐酸盐用途

【用途一】
金和水中游离氯的灵敏性比色测定试剂。

3,3'-二甲基联苯胺盐酸盐名称

[ CAS 号 ]:
612-82-8

[ 中文名 ]:
盐酸-3,3'-二甲基联苯胺

[ 英文名 ]:
4,4'-Bi-o-toluidine dihydrochloride

[中文别名 ]:

[英文别名 ]:

O-TOLIDINE HYDROCHLORIDE
8-Piperazin-1-yl-quinoline
MFCD00012960
3,3'-Dimethyl-4,4'-biphenyldiamine dihydrochloride
3,3'-Dimethyl-benzidin,Dihydrochlorid
o-Tolidine dihydroch
3,3'-Dimethylbiphenyl-4,4'-diamine dihydrochloride
Benzidine, 3,3'-dimethyl-, dihydrochloride
3,3′-Dimethylbenzidine dihydrochloride
3,3'-dimethyl-benzidine,dihydrochloride

3,3'-二甲基联苯胺盐酸盐物理化学性质

[ 沸点 ]:
361ºC at 760 mmHg

[ 熔点 ]:
>300°C

[ 分子式 ]:
C₁₄H₁₈Cl₂N₂

[ 分子量 ]:
285.212

[ 精确质量 ]:
284.084717

[ PSA ]:
52.04000

[ LogP ]:
5.90120

[ 外观性状 ]:
白色至淡黄色

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 水溶解性 ]:
水溶性：可溶；极微溶：乙醇；不溶：乙醚

3,3'-二甲基联苯胺盐酸盐MSDS

详细MSDS(安全技术说明书)

3,3'-二甲基联苯胺盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD1226000

CHEMICAL NAME :: Benzidine, 3,3'-dimethyl-, dihydrochloride

CAS REGISTRY NUMBER :: 612-82-8

LAST UPDATED :: 199709

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C14-H16-N2.2Cl-H

MOLECULAR WEIGHT :: 285.24

WISWESSER LINE NOTATION :: ZR B1 DR DZ C1 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1120 mg/kg/14D-C

TOXIC EFFECTS :: Endocrine - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18200 mg/kg/13W-C

TOXIC EFFECTS :: Endocrine - changes in thymus weight Blood - changes in bone marrow (not otherwise specified) Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1820 mg/kg/65W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15288 mg/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 20 mg/L

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-390,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1372 No. of Facilities: 132 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 1178 (estimated) No. of Female Employees: 105 (estimated)

3,3'-二甲基联苯胺盐酸盐安全信息

[ 符号 ]:

GHS07, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H350-H411

[ 警示性声明 ]:
P201-P273-P301 + P312 + P330-P308 + P313-P391-P501

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R22;R45;R51/53;R68

[ 安全声明 (欧洲) ]:
S53-S45-S61

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
DD1226000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

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3,3'-二甲基联苯胺盐酸盐文献

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4-Aminobyphenyl (4-Ab), benzidine (Bz), and Bz congeners were evaluated for their ability to induce genotoxicity through an oxidative mechanism. The mutagenicity of these compounds was tested in the p...

ortho-Substituent effects on the in vitro and in vivo genotoxicity of benzidine derivatives.

Mutat. Res. 319(1) , 19-30, (1993)

Benzidine and its 3,3'-diamino, 3,3'-dimethyl, 3,3'-dimethoxy, 3,3'-difluoro, 3,3'-dichloro, 3,3'-dibromo, 3,3'-dicarbomethoxy and 3,3'-dinitro derivatives together with 2-nitrobenzidine and 3-nitrobe...

Iron(III) oxidized nucleophilic coupling of catechol with o-tolidine/p-toluidine followed by 1,10-phenanthroline as new and sensitivity improved spectrophotometric methods for iron present in chemicals, pharmaceutical, edible green leaves, nuts and lake water samples.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 86 , 152-8, (2012)

A nucleophile formed from iron(III) oxidized catechol in 0.1M hydrochloric acid couple with o-tolidine, system 1/p-toluidine, system 2 to produce dye product, λ max 520 nm. The system 1/2 obeys Beer's...

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