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螺旋藻甙

螺旋藻甙用途

螺旋藻糖苷是一种口服活性天然化合物,具有抗氧化活性,抑制活性氧(ROS)和丙二醛的产生。螺旋藻糖苷具有抗过敏、抗炎和抗肿瘤活性[1]。

螺旋藻甙名称

[ CAS 号 ]:
20229-56-5

[ 中文名 ]:
绣线菊甙

[ 英文名 ]:
spiraeoside

[英文别名 ]:

Spiraeosid
Quercetin 4'-b-D-glucopyranoside
Quercetin 4'-O-glucoside
Quercetin-4'-glucoside
EINECS 243-614-6
Spiraein
quercetin 4'-O-beta-D-glucopyranoside
Spiraeoside

螺旋藻甙生物活性

[ 描述 ]:

螺旋藻糖苷是一种口服活性天然化合物,具有抗氧化活性,抑制活性氧(ROS)和丙二醛的产生。螺旋藻糖苷具有抗过敏、抗炎和抗肿瘤活性[1]。

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 炎症/免疫

[体外研究]

螺旋藻糖苷提高汞刺激,导致AC16细胞中p-Akt、核Nrf2和HO-1表达水平降低(螺旋藻糖苷的作用被LY294002逆转)[1]。螺旋藻糖苷保护AC16细胞免受汞诱导的氧化应激、细胞损伤和凋亡[1]。在接触汞的AC16细胞中,螺苷激活PI3K/Akt/Nrf2通路[1]。螺旋藻糖苷通过PI3K/Akt/Nrf2途径保护AC16细胞免受汞诱导的凋亡[1]。细胞活力测定[1]细胞系：AC16细胞。浓度：1、5、10或20μM。培养时间：0、24或48小时。结果：抑制AC16细胞活力(20μM)。

[体内研究]

螺旋藻糖苷(50 mg/kg,p.o.)具有预防溃疡的能力[2]。动物模型：雄性Wistar大鼠(6-8周龄)[2]。剂量：50mg/kg。给药：诱导病变前1小时灌胃给药。结果：形成的病变严重程度降低。

[参考文献]

[1]. Hongyang Liu, et al. Spiraeoside protects human cardiomyocytes against high glucose-induced injury, oxidative stress, and apoptosis by activation of PI3K/Akt/Nrf2 pathway. J Biochem Mol Toxicol. 2020 Oct;34(10):e22548.

[2]. Stevan Samardžić, et al. Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench. J Ethnopharmacol. 2018 Mar 1;213:132-137.

螺旋藻甙物理化学性质

[ 密度 ]:
1.809g/cm3

[ 沸点 ]:
835.6ºC at 760mmHg

[ 熔点 ]:
209-211ºC

[ 分子式 ]:
C₂₁H₂₀O₁₂

[ 分子量 ]:
464.37600

[ 闪点 ]:
294.6ºC

[ 精确质量 ]:
464.09500

[ PSA ]:
210.51000

[ 外观性状 ]:
黄色有块状物的粉末

[ 蒸汽压 ]:
1.28E-29mmHg at 25°C

[ 折射率 ]:
1.774

[ 储存条件 ]:
?20°C

螺旋藻甙MSDS

详细MSDS(安全技术说明书)

螺旋藻甙毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3095000

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 2-(4-(beta-D-glucopyranosyloxy)-3-hydroxyphenyl)-3,5, 7-trihydroxy-

CAS REGISTRY NUMBER :: 20229-56-5

LAST UPDATED :: 199503

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C21-H20-C12

MOLECULAR WEIGHT :: 416.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 50 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 246,205,1991

螺旋藻甙安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 危险品运输编码 ]:
NONH for all modes of transport

螺旋藻甙合成路线

详细合成路线

螺旋藻甙上下游产品

螺旋藻甙上游产品

螺旋藻甙下游产品

螺旋藻甙文献

The crystal structure of human cytosolic beta-glucosidase unravels the substrate aglycone specificity of a family 1 glycoside hydrolase.

J. Mol. Biol. 370(5) , 964-75, (2007)

Human cytosolic beta-glucosidase (hCBG) is a xenobiotic-metabolizing enzyme that hydrolyses certain flavonoid glucosides, with specificity depending on the aglycone moiety, the type of sugar and the l...

Flavonoid glycosides inhibit oral cancer cell proliferation--role of cellular uptake and hydrolysis to the aglycones.

J. Pharm. Pharmacol. 57(8) , 1037-42, (2005)

Epidemiologic evidence supports the view that dietary flavonoids exert protective effects in oral diseases, including cancer. However, the dietary forms of flavonoids, the flavonoid glycosides, are th...

Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity.

FEBS Lett. 436(1) , 71-5, (1998)

Flavonoid and isoflavonoid glycosides are common dietary phenolics which may be absorbed from the small intestine of humans. The ability of cell-free extracts from human small intestine and liver to d...

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