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苄达酸

苄达酸用途

【用途一】
用作消炎镇痛剂

苄达酸名称

[ CAS 号 ]:
20187-55-7

[ 中文名 ]:
苄达酸

[ 英文名 ]:
Bendazac

[中文别名 ]:

[英文别名 ]:

bendazolic acid
Bendazacum
Bendazaco
[(1-Benzyl-1H-indazol-3-yl)oxy]acetic acid
Zildasac
(1-Benzyl-1H-indazol-3-yloxy)-acetic acid
1-Benzylindazole-3-oxyacetic acid
Versus
Bendazacum [INN-Latin]
[(1-Benzyl-3-indazolyl)oxy]acetic Acid

苄达酸生物活性

[ 描述 ]:

Bendazac 是一种氧乙酸,具有抗炎、抗过敏、利胆和抗血脂的特性。Bendazac 阻止蛋白质变性,延缓白内障的发生过程。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[体外研究]

本达沙是一种具有蛋白质抗凝血特性的抗炎药,对各种炎症性皮肤病有效。Bendazac被证明是化学氧化系统中的一种强反应底物,它模拟了羟基自由基生成的生理途径[2]。利用自旋标记牛血清白蛋白(BSA)的EPR光谱研究表明,Bendazac可以阻止尿素、热和黄嘌呤氧化酶系统产生的自由基引起的BSA变性[2]。

[参考文献]

[1]. Balfour JA, et al. Bendazac lysine. A review of its pharmacological properties and therapeutic potential in the management of cataracts. Drugs. 1990;39(4):575-596.

[2]. Guglielmotti A, et al. Radical scavenger activity of bendazac, an anticataract non-steroidal anti-inflammatory agent. Pharmacol Res. 1995;32(6):369-373.

[3]. Musci G, et al. Mechanism of the scavenger-like activity of bendazac. Drugs Exp Clin Res. 1987;13(5):289-292.

苄达酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
508.2±35.0 °C at 760 mmHg

[ 熔点 ]:
161-163ºC

[ 分子式 ]:
C₁₆H₁₄N₂O₃

[ 分子量 ]:
282.294

[ 闪点 ]:
261.1±25.9 °C

[ 精确质量 ]:
282.100433

[ PSA ]:
64.35000

[ LogP ]:
3.06

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.630

[ 储存条件 ]:
通风低温干燥

[ 水溶解性 ]:
水溶性：不溶；可溶于：丙酮,氯仿；微溶：乙醇；极微溶：乙醚

苄达酸MSDS

详细MSDS(安全技术说明书)

苄达酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AF5085000

CHEMICAL NAME :: Acetic acid, ((1-benzyl-1H-indazol-3-yl)oxy)-

CAS REGISTRY NUMBER :: 20187-55-7

BEILSTEIN REFERENCE NO. :: 0893958

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C16-H14-N2-O3

MOLECULAR WEIGHT :: 282.32

WISWESSER LINE NOTATION :: T56 BNNJ B1R& DO1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,161,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 319 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 10,884,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 714 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 10,884,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 304 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,161,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1105 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,161,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 339 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 10,884,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 406 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 10,884,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,161,1989

苄达酸安全信息

[ 海关编码 ]:
2933990090

苄达酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

苄达酸