<生产厂家价格>

吡罗霉素

吡罗霉素用途

吡咯霉素是一种大环内酯类抗生素,已在委内瑞拉链球菌中发现,对大肠杆菌、金黄色葡萄球菌和枯草杆菌具有活性[1]。

吡罗霉素名称

[ CAS 号 ]:
19721-56-3

[ 中文名 ]:
吡罗霉素

[ 英文名 ]:
Picromycin

[英文别名 ]:

Albomycetin
picromycin
Pikromycin
Amaromycin

吡罗霉素生物活性

[ 描述 ]:

吡咯霉素是一种大环内酯类抗生素,已在委内瑞拉链球菌中发现,对大肠杆菌、金黄色葡萄球菌和枯草杆菌具有活性[1]。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Gupta S, et al. Generation of novel pikromycin antibiotic products through mutasynthesis. Chembiochem. 2008 Jul 2;9(10):1609-16.

吡罗霉素物理化学性质

[ 密度 ]:
1.14g/cm3

[ 沸点 ]:
688.1ºC at 760mmHg

[ 分子式 ]:
C₂₈H₄₇NO₈

[ 分子量 ]:
525.67

[ 闪点 ]:
369.9ºC

[ 精确质量 ]:
525.33000

[ PSA ]:
122.60000

[ LogP ]:
2.51290

[ 蒸汽压 ]:
6.51E-22mmHg at 25°C

[ 折射率 ]:
1.521

吡罗霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TJ8225000

CHEMICAL NAME :: Picromycin

CAS REGISTRY NUMBER :: 19721-56-3

LAST UPDATED :: 199510

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C28-H47-N-O8

MOLECULAR WEIGHT :: 525.76

WISWESSER LINE NOTATION :: T-12-OV HV IUTJ C1 E1 G1 KQ K1 L2 FO- BT6OTJ CQ DN1&1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,287,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,114,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 249 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,114,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,114,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,144,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 508 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,101,1978