雌三醇-16beta-D-葡糖苷酸

雌三醇-16beta-D-葡糖苷酸用途

雌二醇16α-(β-D-葡萄糖醛酸)是尿中的内源性代谢产物,可用于妊娠研究[1][2]。

雌三醇-16beta-D-葡糖苷酸名称

[ CAS 号 ]:
1852-50-2

[ 中文名 ]:
雌三醇-16beta-D-葡糖苷酸

[ 英文名 ]:
Estriol 16α-(β-D-glucuronide)

[中文别名 ]:

雌三醇-16alfa-(beta-D-葡糖苷酸)

[英文别名 ]:

estriol 16 glucuronide
Estriol O16-glucuronide

雌三醇-16beta-D-葡糖苷酸生物活性

[ 描述 ]:

雌二醇16α-(β-D-葡萄糖醛酸)是尿中的内源性代谢产物,可用于妊娠研究[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

[体外研究]

内源性代谢产物被定义为《京都基因和基因组百科全书》注释为我们基因组中约1900种代谢酶的底物或产物。在文献正文中很清楚,许多这些代谢产物都具有毒性[1]。

[参考文献]

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.

[2]. Yang YJ, et al. Direct determination of estriol 3- and 16-glucuronides in pregnancy urine by column-switching liquid chromatography with electrospray tandem mass spectrometry. Biomed Chromatogr. 2003 Jun;17(4):219-25.

雌三醇-16beta-D-葡糖苷酸物理化学性质

[ 密度 ]:
1.51g/cm3

[ 沸点 ]:
738.3ºC at 760mmHg

[ 分子式 ]:
C₂₄H₃₂O₉

[ 分子量 ]:
464.50500

[ 闪点 ]:
253.5ºC

[ 精确质量 ]:
464.20500

[ PSA ]:
156.91000

[ LogP ]:
0.49650

[ 蒸汽压 ]:
6.95E-23mmHg at 25°C

[ 折射率 ]:
1.667

[ 储存条件 ]:
-20°C

雌三醇-16beta-D-葡糖苷酸安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H351

[ 警示性声明 ]:
P281

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
40

[ 安全声明 (欧洲) ]:
36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

雌三醇-16beta-D-葡糖苷酸合成路线

详细合成路线

雌三醇-16beta-D-葡糖苷酸上下游产品

雌三醇-16beta-D-葡糖苷酸上游产品

雌三醇-16beta-D-葡糖苷酸下游产品

雌三醇-16beta-D-葡糖苷酸文献

Radioimmunoassay of 2-hydroxyestrone.

Steroids 31(2) , 249-58, (1978)

Under the protection of ascorbic acid a 2-hydroxyestrone bovine serum albumin conjugate was prepared containing intact 2-hydroxyestrone as determined by gas chromatographymass spectometry. Using this ...

The dynamic changes of several reproductive hormones during termination of early pregnancy by RU486 in combination with PG-05 in Chinese women.

Adv. Contracept. 4(4) , 319-26, (1988)

8 pregnant women (below 49 days of amenorrhea) were administered 600 mg RU486 orally in a single dosage, and 1 mg PG-05 as a vaginal suppository 48 h afterwards. The plasma beta-hCG, progesterone, 17 ...

Associations between urinary phthalate monoesters and thyroid hormones in pregnant women.

Hum. Reprod. 22(10) , 2715-22, (2007)

Maternal hypothyroidism during pregnancy can cause adverse effects in the fetus. Scientific evidence has shown that probable thyroid-like function of some phthalates in vitro and in vivo, and phthalat...

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