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富马酸钠

富马酸钠用途

富马酸(二钠)是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

富马酸钠名称

[ CAS 号 ]:
17013-01-3

[ 中文名 ]:
富马酸钠

[ 英文名 ]:
sodium fumarate

[中文别名 ]:

[英文别名 ]:

2-Butenedioic acid, sodium salt, (2E)- (1:2)
Disodium (2E)-but-2-enedioate
2-Butenedioic acid (E)-, sodium salt
FUMARIC ACID SODIUM SALT
sodium fumarate
UNII:0578QTK490
MFCD00064567
(E)-2-Butenedioic acid disodium salt
EINECS 241-087-7
Disodium (2E)-2-butenedioate

富马酸钠生物活性

[ 描述 ]:

富马酸(二钠)是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

富马酸钠物理化学性质

[ 沸点 ]:
355.5ºC at 760 mmHg

[ 分子式 ]:
C₄H₂Na₂O₄

[ 分子量 ]:
160.036

[ 闪点 ]:
183ºC

[ 精确质量 ]:
159.974854

[ PSA ]:
80.26000

[ 外观性状 ]:
白色

[ 蒸汽压 ]:
5.19E-06mmHg at 25°C

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

[ 水溶解性 ]:
228 g/L

富马酸钠MSDS

富马酸钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LT1830000

CHEMICAL NAME :: Fumaric acid, disodium salt

CAS REGISTRY NUMBER :: 17013-01-3

LAST UPDATED :: 199107

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C4-H2-O4.2Na

MOLECULAR WEIGHT :: 160.04

WISWESSER LINE NOTATION :: QV1U1VQ &-NA- 2 -T

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 215 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting Gastrointestinal - other changes

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 31,1,1942

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,314,1986

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2420 mg/kg

TOXIC EFFECTS :: Behavioral - irritability Blood - hemorrhage Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 35,298,1946

TYPE OF TEST :: LD10 - Lethal Dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3680 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 31,12,1942

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 31,1,1942

富马酸钠安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
LT1830000

[ 海关编码 ]:
2917190090

富马酸钠合成路线

富马酸钠上下游产品

富马酸钠上游产品

富马酸钠下游产品

富马酸钠制备

反丁烯二酸经碳酸钠中和而得。将水加热至沸，搅拌下加入反丁烯二酸。分次加入碳酸钠至pH=6.5-6.7。充分搅拌，趁热过滤，得反丁烯二酸钠溶液。

富马酸钠海关

[ 海关编码 ]: 2917190090

[ 中文概述 ]:
2917190090 其他无环多元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

富马酸钠文献

Serially coupling hydrophobic interaction and reversed-phase chromatography with simultaneous gradients provides greater coverage of the metabolome.

Metabolomics 11 , 1465-1470, (2015)

The serial coupling of a reversed-phase liquid chromatography (RPLC) column to a hydrophilic interaction liquid chromatography (HILIC) column has been developed in recent years for the detection of po...

Use of transposase and ends of IS608 enables precise and scarless genome modification for modulating gene expression and metabolic engineering applications in Escherichia coli.

Biotechnol. J. 11 , 80-90, (2016)

Various methods have been developed for gene disruption in bacteria; however, extra in vitro manipulation steps or the residual presence of a scar in the host chromosome limits the use of such methods...

Functional characterization of solute carrier (SLC) 26/sulfate permease (SulP) proteins in membrane mimetic systems.

Biochim. Biophys. Acta 1858 , 698-705, (2016)

Solute carrier (SLC) 26 or sulfate permease (SulP) anion transporters, belong to a phylogenetically ancient family of secondary active transporters. Members of the family are involved in several human...

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