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胰高血糖素

胰高血糖素用途

Glucagon是一种多肽激素,有助于调节体内的血糖(葡萄糖)水平。

胰高血糖素名称

[ CAS 号 ]:
16941-32-5

[ 中文名 ]:
胰高血糖素

[ 英文名 ]:
glucagonTFA

[中文别名 ]:

[英文别名 ]:

Glucagon
GLUCAGON 1-37
GLUCAGON ACETATE
OXYNTOMODULIN
GLUCAGON 37
Glucagon 1-29
Glucaton
OXYNTOMODULIN (PORCINE)
Glucagon Hydrochloride

胰高血糖素生物活性

[ 描述 ]:

Glucagon是一种多肽激素,有助于调节体内的血糖(葡萄糖)水平。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 胰高血糖素受体

研究领域 >> 代谢疾病

多肽产品

[体外研究]

胰高血糖素可纠正DIO小鼠的血脂异常,肥胖和高血糖。当胰高血糖素与胰高血糖素受体结合时,肝细胞将糖原转化为单个葡萄糖分子并将其释放到血液中,这一过程称为糖原分解[1] [2]。

[参考文献]

[1]. Finan B et al. Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease. Cell. 2016 Oct 20;167(3):843-857.

[2]. Kristensen PL et al. Impact of the TCF7L2 genotype on risk of hypoglycaemia and glucagon secretion during hypoglycaemia. Endocr Connect. 2016 Oct 10.

[相关活性小分子]

胰高血糖素物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 分子式 ]:
C₁₅₃H₂₂₅N₄₃O₄₉S

[ 分子量 ]:
3482.747

[ 精确质量 ]:
3480.615723

[ PSA ]:
1564.04000

[ LogP ]:
-6.01

[ 外观性状 ]:
powder

[ 折射率 ]:
1.682

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
Practically insoluble in water and in most organic solvents. It is soluble in dilute mineral acids and in dilute solutions of alkali hydroxides.

胰高血糖素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

胰高血糖素文献

Over-expression of Follistatin-like 3 attenuates fat accumulation and improves insulin sensitivity in mice.

Metab. Clin. Exp. 64(2) , 283-95, (2015)

Follistatin-like 3 (fstl3), a natural inhibitor of members of the TGF-β family, increases during resistance training in human plasma. Fstl3 primarily binds myostatin and activin A, and thereby inhibit...

Progenitor potential of nkx6.1-expressing cells throughout zebrafish life and during beta cell regeneration.

BMC Biol. 13 , 70, (2015)

In contrast to mammals, the zebrafish has the remarkable capacity to regenerate its pancreatic beta cells very efficiently. Understanding the mechanisms of regeneration in the zebrafish and the differ...

Co-expression of the homologous proteases fibroblast activation protein and dipeptidyl peptidase-IV in the adult human Langerhans islets.

Histochem. Cell Biol. 143(5) , 497-504, (2015)

Fibroblast activation protein (FAP, seprase, EC 3.4.21.B28) and dipeptidyl peptidase-IV (DPP-IV, CD26, EC 3.4.14.5) are homologous serine proteases implicated in the modulation of the bioavailability ...

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