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地黄苷元

地黄苷元用途

Digoxigenin是半抗原,是具有较高抗原性的小分子,用于许多分子生物学应用,作为替代探针,用于标记原位杂交

地黄苷元名称

[ CAS 号 ]:
1672-46-4

[ 中文名 ]:
地黄苷元

[ 英文名 ]:
Digoxigenin

[中文别名 ]:

异羟黄毒苷

[英文别名 ]:

Lanadigenin
digitoxigenin
MFCD00871861
Lanadigigenin
Digoxigenine
Digoxigenin
EINECS 216-806-2

地黄苷元生物活性

[ 描述 ]:

Digoxigenin是半抗原,是具有较高抗原性的小分子,用于许多分子生物学应用,作为替代探针,用于标记原位杂交

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[相关活性小分子]

地黄苷元物理化学性质

[ 密度 ]:
1.297 g/cm3

[ 沸点 ]:
589.4ºC at 760 mmHg

[ 熔点 ]:
222 °C(lit.)

[ 分子式 ]:
C₂₃H₃₄O₅

[ 分子量 ]:
390.51300

[ 闪点 ]:
203ºC

[ 精确质量 ]:
390.24100

[ PSA ]:
86.99000

[ LogP ]:
2.57510

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
2.4E-16mmHg at 25°C

[ 折射率 ]:
1.609

[ 储存条件 ]:
2-8℃

地黄苷元MSDS

详细MSDS(安全技术说明书)

地黄苷元毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FH5390000

CHEMICAL NAME :: 5-beta-Card-20(22)-enolide, 3-beta,12-beta,14-trihydroxy-

CAS REGISTRY NUMBER :: 1672-46-4

BEILSTEIN REFERENCE NO. :: 0096479

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C23-H34-O5

MOLECULAR WEIGHT :: 390.57

WISWESSER LINE NOTATION :: L E5 B666TJ A1 DQ E1 F- DT5OV CUTJ IQ OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 244 ug/kg

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting

REFERENCE :: JPHAA3 Journal of the American Pharmaceutical Association. (Washington, DC) V.1-28, 1912-39; New series: V.1-17, 1961-77. Volume(issue)/page/year: 27,189,1938

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 285 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,55,1963

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3545 ug/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Behavioral - convulsions or effect on seizure threshold Cardiac - other changes

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 153,436,1965

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 1620 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 8,18,1960 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,190,1963

地黄苷元安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H310-H330

[ 警示性声明 ]:
P260-P264-P280-P284-P302 + P350-P310

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
R26/27/28

[ 安全声明 (欧洲) ]:
S36/37/39-S45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
FH5390000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

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地黄苷元文献

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Long-distance retinoid signaling in the zebra finch brain.

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Type I interferons are pivotal in the activation of autoimmune response in systemic lupus erythematous. However, the pathogenic role of interferon-alpha in patients affected by lupus nephritis remains...

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