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去氨加压素

去氨加压素用途

Desmopressin(DDAVP)是抗利尿激素精氨酸加压素的合成类似物。

去氨加压素名称

[ CAS 号 ]:
16679-58-6

[ 中文名 ]:
去氨加压素

[ 英文名 ]:
(Deamino-Cys1,D-Arg8)-Vasopressin acetate salt

[中文别名 ]:

[英文别名 ]:

DESAMINO-[D-ARG8]VASOPRESSIN
Desmopressin
DDAVP
DESMOPRESSIN,HUMAN
Mep(mercaptopropionic acid)-YFQNCPdRG-NH2
DDAVP,HUMAN
[DEAMINO1,DARG8] VASOPRESSIN
M.W. 1069.22 C46H64N14O12S2
DESMOPRESSIN ACETATE PH. EUR.
[DEAMINO-CYS1,D-ARG8]-VASOPRESSIN

去氨加压素生物活性

[ 描述 ]:

Desmopressin(DDAVP)是抗利尿激素精氨酸加压素的合成类似物。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管加压素受体

研究领域 >> 代谢疾病

天然产物 >> 其他

多肽产品

[参考文献]

[1]. Vande Walle J, Stockner M, Raes A, N?rgaard JP. Desmopressin 30 years in clinical use: a safety review. Curr Drug Saf. 2007 Sep;2(3):232-8.

[2]. Franchini M, Zaffanello M, Lippi G. The use of desmopressin in mild hemophilia A. Blood Coagul Fibrinolysis. 2010 Oct;21(7):615-9.

[3]. Sánchez-Luceros A, Meschengieser SS, Woods AI et al. Biological and clinical response to desmopressin (DDAVP) in a retrospective cohort study of children with low von Willebrand factor levels and bleeding history. Thromb Haemost. 2010 Nov;104(5):984-9.

[4]. Alonso DF, Ripoll GV, Garona J et al. Metastasis: recent discoveries and novel perioperative treatment strategies with particular interest in the hemostatic compound desmopressin. Curr Pharm Biotechnol. 2011 Nov;12(11):1974-80.

[5]. Tsukamoto I. Recent patenting activities in the discovery and development of vasopressin V2 receptor agonists. Expert Opin Ther Pat. 2012 Jun;22(6):579-86.

[相关活性小分子]

去氨加压素物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 分子式 ]:
C₄₆H₆₄N₁₄O₁₂S₂

[ 分子量 ]:
1069.217

[ 精确质量 ]:
1068.427002

[ PSA ]:
486.01000

[ LogP ]:
-5.82

[ 折射率 ]:
1.713

去氨加压素安全信息

[ 海关编码 ]:
2937190090

去氨加压素海关

[ 海关编码 ]: 2937190090

去氨加压素文献

Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin.

AAPS J. 16(4) , 875-83, (2014)

The effect of food intake on the release and degradation of peptide drugs from solid lipid particles is unknown and was therefore investigated in vitro using different fed state media in a lipolysis m...

Abnormal fluid homeostasis in apelin receptor knockout mice.

J. Endocrinol. 202(3) , 453-62, (2009)

The apelinergic system, comprised of apelin and its G protein-coupled receptor (APJ; APLNR as given in MGI Database), is expressed within key regions of the central nervous system associated with argi...

In vitro models for metabolic studies of small peptide hormones in sport drug testing.

J. Pept. Sci. 21(1) , 1-9, (2014)

Peptide hormones represent an emerging class of potential doping agents. Detection of their misuse is difficult due to their short half-life in plasma and rapid elimination. Therefore, investigating t...

更多文献

去氨加压素

去氨加压素用途

去氨加压素名称

去氨加压素生物活性

去氨加压素物理化学性质

去氨加压素安全信息

去氨加压素海关

去氨加压素文献

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