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盐酸纳曲酮

盐酸纳曲酮用途

盐酸纳曲酮主要用于对已解除阿片类药物毒瘾者的康复期辅助治疗,使戒除阿片瘾者能维正常生活,防止或减少复吸。

盐酸纳曲酮名称

[ CAS 号 ]:
16676-29-2

[ 中文名 ]:
盐酸纳曲酮

[ 英文名 ]:
Naltrexone Hydrochloride

[中文别名 ]:

纳曲酮盐酸盐

[英文别名 ]:

EINECS 240-723-0
MFCD00069324
Naltrexone hydrochloride
Naltrexone HCl

盐酸纳曲酮物理化学性质

[ 密度 ]:
1.47 g/cm3

[ 沸点 ]:
558.1ºC at 760 mmHg

[ 熔点 ]:
274-2760C

[ 分子式 ]:
C₂₀H₂₄ClNO₄

[ 分子量 ]:
377.862

[ 闪点 ]:
291.4ºC

[ 精确质量 ]:
377.139374

[ PSA ]:
70.00000

[ LogP ]:
2.26530

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
2.71E-13mmHg at 25°C

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: 50 mg/mL, clear, colorless

盐酸纳曲酮MSDS

盐酸纳曲酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QD2160000

CHEMICAL NAME :: Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-alpha-oxy-3,14-dihydoxy-, hydrochloride

CAS REGISTRY NUMBER :: 16676-29-2

LAST UPDATED :: 199712

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C20-H23-N-O4.Cl-H

MOLECULAR WEIGHT :: 377.90

WISWESSER LINE NOTATION :: T B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ CQ JQ P1- AL3TJ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1490 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1100 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Human Fibroblast

DOSE/DURATION :: 100 mg/L

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 1,103,1978

盐酸纳曲酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
QD2160000

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盐酸纳曲酮文献

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Chemical genetics reveals a complex functional ground state of neural stem cells.

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Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...

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