枸橼酸乙胺嗪
枸橼酸乙胺嗪用途
枸橼酸乙胺嗪名称
[ CAS 号 ]:
1642-54-2
[ 中文名 ]:
枸橼酸乙胺嗪
[ 英文名 ]:
Diethylcarbamazine Citrate
[中文别名 ]:
[英文别名 ]:
- MFCD00039124
- Diethylcarbamazine citrate
- EINECS 216-696-6
- Diethylcarbamazine (citrate)
枸橼酸乙胺嗪生物活性
[ 描述 ]:
[ 相关类别 ]:
[参考文献]
[相关活性小分子]
枸橼酸乙胺嗪物理化学性质
[ 沸点 ]:
297.4ºC at 760 mmHg
[ 熔点 ]:
140 °C
[ 分子式 ]:
C16H29N3O8
[ 分子量 ]:
391.417
[ 闪点 ]:
116.6ºC
[ 精确质量 ]:
391.195465
[ PSA ]:
158.92000
[ 外观性状 ]:
固体;White to Almost white powder to crystal
[ 储存条件 ]:
-20°C Freezer
枸橼酸乙胺嗪MSDS
枸橼酸乙胺嗪毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TL1225000
- CAS REGISTRY NUMBER :
- 1642-54-2
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C10-H21-N3-O.C6-H8-O7
- MOLECULAR WEIGHT :
- 391.48
- WISWESSER LINE NOTATION :
- T6N DNTJ AVN2&2 D1 &OV1XQVO&1VO
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 309 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,63,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1136 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,306,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 660 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,41,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 425 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IJSBDB Indian Journal of Chemistry, Section B: Organic Chemistry, Including Medicinal Chemistry. (Publications & Information Directorate, Council of Scientific and Industrial Research (CSIR), Hillside Rd., New Delhi 110 012, India) V.14B- 1976- Volume(issue)/page/year: 26,748,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 608 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,306,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 180 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00466 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 14 mg/kg/7D-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - changes in sodium Nutritional and Gross Metabolic - changes in calcium Nutritional and Gross Metabolic - changes in phosphorus
- REFERENCE :
- BIOKE3 Biokemistri. (Klobex Academic Publishers, POB 4216, Ilorin, Nigiria) V.1- 1994- Volume(issue)/page/year: 5,125,1995 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1800 mg/kg
- SEX/DURATION :
- female 8-16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Volume(issue)/page/year: 60,1529,1972 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1545 No. of Facilities: 611 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 5223 (estimated) No. of Female Employees: 2464 (estimated)
枸橼酸乙胺嗪安全信息
[ 符号 ]:
GHS06
[ 信号词 ]:
Danger
[ 危害声明 ]:
H302-H330
[ 警示性声明 ]:
P260-P301 + P312 + P330-P304 + P340 + P310-P403 + P233
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ 危害码 (欧洲) ]:
T+: Very toxic;
[ 风险声明 (欧洲) ]:
R22
[ 安全声明 (欧洲) ]:
S22-S36/37/39-S45
[ 危险品运输编码 ]:
UN 2811 6.1/PG 2
[ WGK德国 ]:
3
[ RTECS号 ]:
TL1225000
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1(b)
[ 海关编码 ]:
2933599090
枸橼酸乙胺嗪海关
[ 海关编码 ]: 2933599090
[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
枸橼酸乙胺嗪文献
J. Pharm. Biomed. Anal. 98 , 307-10, (2014)
A sensitive and selective liquid chromatographic method using mass spectrometric detection was developed for the determination of diethylcarbamazine (DEC) in human plasma. DEC and its stable isotope i...
Immunomodulatory effect of diethylcarbamazine in mice infected with Nocardia brasiliensis.Int. Immunopharmacol. 23(1) , 113-20, (2015)
We tested whether diethylcarbamazine (DEC) or ivermectin (IVM), both antiparasitic drugs with reported immunomodulatory properties, were able to affect the immune system to potentiate host defense mec...
Loa loa—does it deserve to be neglected?Lancet Infect. Dis. 14(4) , 353-7, (2014)
More than 10 million people in western and central Africa are estimated to be infected with Loa loa filarial nematodes. Like most other infectious diseases, L loa filariasis (loiasis) covers a wide ra...
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公司名:上海吉至生化科技有限公司
区域:上海市奉贤区
价格:
¥348.0/250mg
联系人:刘佳
产品详情:枸橼酸乙胺嗪
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥98.0/1g
联系人:夏言
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥108.9/1g
¥350.9/5g
¥720.9/1ml
¥1181.9/25g
联系人:阿拉丁李高志
产品详情:乙胺嗪柠檬酸盐
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相关化合物
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