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2-氨基-N-(喹啉-8-基)苯磺酰胺

2-氨基-N-(喹啉-8-基)苯磺酰胺用途

NUN82647在G2期抑制细胞周期并诱导凋亡【1】。

2-氨基-N-(喹啉-8-基)苯磺酰胺名称

[ CAS 号 ]:
16082-64-7

[ 中文名 ]:
2-氨基-N-喹啉-8-基-苯磺酰胺

[ 英文名 ]:
QBS

[英文别名 ]:

AmbscL35/057
2-AMINO-N-QUINOLINE-8-YLBENZENESULFONAMIDE
N-(quinolin-8-yl)-2-amino-benzenesulfonamide
8-(2-Aminophenylsulfonylamino)chinolin
QBS
2-Amino-N-quinolin-8-yl-benzenesulfonamide

2-氨基-N-(喹啉-8-基)苯磺酰胺生物活性

[ 描述 ]:

NUN82647在G2期抑制细胞周期并诱导凋亡【1】。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

[参考文献]

[1]. Kim YH, et al. G2 arrest and apoptosis by 2-amino-N-quinoline-8-yl-benzenesulfonamide (QBS), a novel cytotoxic compound. Biochem Pharmacol. 2005 May 1;69(9):1333-41.

2-氨基-N-(喹啉-8-基)苯磺酰胺物理化学性质

[ 密度 ]:
1.437g/cm3

[ 沸点 ]:
540.7ºC at 760 mmHg

[ 分子式 ]:
C₁₅H₁₃N₃O₂S

[ 分子量 ]:
299.35

[ 闪点 ]:
280.8ºC

[ 精确质量 ]:
299.07300

[ PSA ]:
93.46000

[ LogP ]:
4.35280

[ 蒸汽压 ]:
9.36E-12mmHg at 25°C

[ 折射率 ]:
1.727

[ 储存条件 ]:
2-8°C

2-氨基-N-(喹啉-8-基)苯磺酰胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2935009090

2-氨基-N-(喹啉-8-基)苯磺酰胺合成路线

详细合成路线

2-氨基-N-(喹啉-8-基)苯磺酰胺上下游产品

2-氨基-N-(喹啉-8-基)苯磺酰胺上游产品

2-氨基-N-(喹啉-8-基)苯磺酰胺下游产品

2-氨基-N-(喹啉-8-基)苯磺酰胺海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

2-氨基-N-(喹啉-8-基)苯磺酰胺文献

G2 arrest and apoptosis by 2-amino-N-quinoline-8-yl-benzenesulfonamide (QBS), a novel cytotoxic compound.

Biochem. Pharmacol. 69 , 1333-1341, (2005)

We screened a library of 11,000 small molecular weight chemicals, looking for compounds that affect cell viability. We have identified 2-amino-N-quinoline-8-yl-benzenesulfonamide (QBS) as a potent cyt...

ADAM-mediated amphiregulin shedding and EGFR transactivation.

Cell Prolif. 42 , 799-812, (2009)

The ectodomain shedding of epidermal growth factor receptor (EGFR) ligands, such as amphiregulin (AREG), by ADAMs (A Disintegrin And Metalloproteases) can be stimulated by G protein-coupled receptor (...

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