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半胱胺盐酸盐

半胱胺盐酸盐用途

Cysteamine盐酸盐可用于肾病型胱胺酸症和作为抗氧化剂。

半胱胺盐酸盐名称

[ CAS 号 ]:
156-57-0

[ 中文名 ]:
半胱胺盐酸盐

[ 英文名 ]:
Cysteamine Hydrochloride

[中文别名 ]:

[英文别名 ]:

2-AMino&CYSTEAMINE HCL
1-Amino-2-mercaptoethane hydrochloride
2-aminoethylmercaptan hydrochloride
2-Mercapto ethyl amine hydrochloride
EINECS 205-858-1
β-Mercapto ethylamine hydrochloride
CYSTEAMINE HCL SOLID
Cysteinamine Hydrochloride
thiol hydrochloride
2-Mercaptoethylamine hydrochloride

半胱胺盐酸盐生物活性

[ 描述 ]:

Cysteamine盐酸盐可用于肾病型胱胺酸症和作为抗氧化剂。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

研究领域 >> 代谢疾病

[参考文献]

[1]. Besouw, M., et al., Cysteamine: an old drug with new potential. Drug Discov Today, 2013. 18(15-16): p. 785-92.

[2]. de Matos, D.G., et al., Effect of cysteamine on glutathione level and developmental capacity of bovine oocyte matured in vitro. Mol Reprod Dev, 1995. 42(4): p. 432-6.

[相关活性小分子]

半胱胺盐酸盐物理化学性质

[ 密度 ]:
0.75

[ 沸点 ]:
116.4ºC at 760 mmHg

[ 熔点 ]:
67-71 °C

[ 分子式 ]:
C₂H₈ClNS

[ 分子量 ]:
113.610

[ 闪点 ]:
24.2ºC

[ 精确质量 ]:
113.006599

[ PSA ]:
64.82000

[ LogP ]:
1.37720

[ 外观性状 ]:
白色结晶粉末带有一种强烈的和不愉快的气味

[ 蒸汽压 ]:
16.7mmHg at 25°C

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable, but hygroscopic. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
VERY SOLUBLE

半胱胺盐酸盐MSDS

半胱胺盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KJ0200000

CHEMICAL NAME :: Ethanethiol, 2-amino-, hydrochloride

CAS REGISTRY NUMBER :: 156-57-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C2-H7-N-S.Cl-H

MOLECULAR WEIGHT :: 113.62

WISWESSER LINE NOTATION :: Z2SH &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1352 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 244 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 5 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 153,57,1985

半胱胺盐酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S36/37/39-S26

[ 危险品运输编码 ]:
UN 3335

[ WGK德国 ]:
3

[ RTECS号 ]:
KJ0200000

[ 海关编码 ]:
2921199090

半胱胺盐酸盐合成路线

半胱胺盐酸盐上下游产品

半胱胺盐酸盐上游产品

半胱胺盐酸盐下游产品

半胱胺盐酸盐制备

【方法一】
以2-氨基乙醇为原料，经氢溴酸溴化，再于硫酸、二硫化碳反应环合，最后盐酸水解而得。

半胱胺盐酸盐海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

半胱胺盐酸盐文献

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Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

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