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西美曲特

西美曲特用途

西美瑞德是一种镇痛剂。Simeicui用于止痛[1]。

西美曲特名称

[ CAS 号 ]:
154-82-5

[ 中文名 ]:
西美曲特

[ 英文名 ]:
Simetride

[英文别名 ]:

Simetridum [INN-Latin]
Kyorin AP 2
Simetride
Simetrida [INN-Spanish]
Simetridum
AP 2

西美曲特生物活性

[ 描述 ]:

西美瑞德是一种镇痛剂。Simeicui用于止痛[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Mlyczyńska E, et, al. Anti-Apoptotic Effect of Apelin in Human Placenta: Studies on BeWo Cells and Villous Explants from Third-Trimester Human Pregnancy. Int J Mol Sci. 2021 Mar 9;22(5):2760.

西美曲特物理化学性质

[ 密度 ]:
1.147g/cm3

[ 沸点 ]:
682.6ºC at 760 mmHg

[ 分子式 ]:
C₂₈H₃₈N₂O₆

[ 分子量 ]:
498.61100

[ 闪点 ]:
366.6ºC

[ 精确质量 ]:
498.27300

[ PSA ]:
77.54000

[ LogP ]:
3.61320

[ 蒸汽压 ]:
1.73E-18mmHg at 25°C

[ 折射率 ]:
1.548

[ 储存条件 ]:
-20°C

西美曲特毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TK9700000

CHEMICAL NAME :: Piperazine, 1,4-bis((2-methoxy-4-propylphenoxy)acetyl)-

CAS REGISTRY NUMBER :: 154-82-5

BEILSTEIN REFERENCE NO. :: 0772468

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C28-H38-N2-O6

MOLECULAR WEIGHT :: 498.68

WISWESSER LINE NOTATION :: T6N DNTJ AV1OR D3 BO1& DV1OR D3 BO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1025 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,206,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 85,715,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85IPAE "Modern Pharmaceuticals of Japan, III," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1968 Volume(issue)/page/year: -,84,1968

西美曲特安全信息

[ 海关编码 ]:
2933599090

西美曲特海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%