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氟可龙

氟可龙用途

Fluocortolone 是一种口服有效的抗炎剂,可有效降低血浆纤维蛋白原水平。Fluocortolone 在大鼠的佐剂关节型炎症模型中抑制 Mycobacterium butyricum 诱导的足部水肿 (3-12 mg/kg)。

氟可龙名称

[ CAS 号 ]:
152-97-6

[ 中文名 ]:
氟可龙

[ 英文名 ]:
Fluocortolone

[英文别名 ]:

FLUORCORTOLONE
SH-742
6a-Fluoro-16a-methyl-1-dehydrocorticosterone
Fluorocortolone
Fluocortolon
flucortolone
EINECS 205-811-5
methylfluorodehydrocorticosterone
Fluocortolone

氟可龙生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Bhargava A S. Effect of anti-inflammatory agents on adjuvant-induced edema modified for primary test[J]. Pharmacological Research Communications, et al. Effect of anti-inflammatory agents on adjuvant-induced edema modified for primary test[J]. Pharmacological Research Communications, 1971, 3(1): 83-91. .

氟可龙物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
537.4±50.0 °C at 760 mmHg

[ 熔点 ]:
113-116ºC

[ 分子式 ]:
C₂₂H₂₉FO₄

[ 分子量 ]:
376.462

[ 闪点 ]:
278.8±30.1 °C

[ 精确质量 ]:
376.204987

[ PSA ]:
74.60000

[ LogP ]:
1.86

[ 外观性状 ]:
淡黄色固体

[ 蒸汽压 ]:
0.0±3.2 mmHg at 25°C

[ 折射率 ]:
1.572

[ 储存条件 ]:
2~8°C

氟可龙毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU3832500

CHEMICAL NAME :: Pregna-1,4-diene-3,20-dione, 6-alpha-fluoro-11-beta,21-dihydroxy-16-alpha-methyl-

CAS REGISTRY NUMBER :: 152-97-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C22-H29-F-O4

MOLECULAR WEIGHT :: 376.51

WISWESSER LINE NOTATION :: L E5 B666 OV AHTTT&J A1 CQ E1 FV1Q G1 LF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 70 mg/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: YKRYAH Yakubutsu Ryoho. Medicinal Treatment. (Tokyo, Japan) V.1-14, 1968-81. Suspended. Volume(issue)/page/year: 9,1623,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 20 mg/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: YKRYAH Yakubutsu Ryoho. Medicinal Treatment. (Tokyo, Japan) V.1-14, 1968-81. Suspended. Volume(issue)/page/year: 9,1623,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 70 mg/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: YKRYAH Yakubutsu Ryoho. Medicinal Treatment. (Tokyo, Japan) V.1-14, 1968-81. Suspended. Volume(issue)/page/year: 9,1623,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 70 mg/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: YKRYAH Yakubutsu Ryoho. Medicinal Treatment. (Tokyo, Japan) V.1-14, 1968-81. Suspended. Volume(issue)/page/year: 9,1623,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 2500 ug/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: AMBED4 AMI-Berichte. (Berlin, Fed. Rep. Ger.) No. 1-2, 1978-82. Volume(issue)/page/year: (1),127,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 30 mg/kg

SEX/DURATION :: female 7-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: YKRYAH Yakubutsu Ryoho. Medicinal Treatment. (Tokyo, Japan) V.1-14, 1968-81. Suspended. Volume(issue)/page/year: 10,151,1977

氟可龙安全信息

[ 危害码 (欧洲) ]:
Xn

[ 海关编码 ]:
2942000000

氟可龙海关

[ 海关编码 ]: 2942000000

氟可龙