异烟腙

异烟腙用途

氟噻嗪具有抗结核活性[1]。

异烟腙名称

[ CAS 号 ]:
149-17-7

[ 中文名 ]:
异烟腙

[ 英文名 ]:
Ftivazide

[英文别名 ]:

Isonicotinic acid vanillylidenehydrazide
Phthivazid
Phtivazide
Isonicotinsaeure-vanillylidenhydrazid
Ftivazide
Vancide
Vanizide
Phthivazidum
Vanillaberon

异烟腙生物活性

[ 描述 ]:

氟噻嗪具有抗结核活性[1]。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Dmitriy Khrustalev, et al. Synthesis of anti-tuberculosis drugs in a microwave flow reactor. Materials Today: Proceedings, 2023, 81: 1186-1191.

异烟腙物理化学性质

[ 密度 ]:
1.3g/cm3

[ 沸点 ]:
441.6ºC at 760 mmHg

[ 熔点 ]:
219-220°C (lit.)

[ 分子式 ]:
C₁₄H₁₃N₃O₃

[ 分子量 ]:
271.27

[ 闪点 ]:
220.9ºC

[ 精确质量 ]:
271.09600

[ PSA ]:
83.81000

[ LogP ]:
1.95060

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
5.36E-08mmHg at 25°C

[ 折射率 ]:
1.619

[ 储存条件 ]:
室温

异烟腙MSDS

详细MSDS(安全技术说明书)

异烟腙毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NS2298000

CHEMICAL NAME :: Isonicotinic acid, vanillylidenehydrazide

CAS REGISTRY NUMBER :: 149-17-7

BEILSTEIN REFERENCE NO. :: 0234808

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H13-N3-O3

MOLECULAR WEIGHT :: 271.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 24960 mg/kg/1Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors

REFERENCE :: VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 18(6),50,1972

异烟腙安全信息

[ 海关编码 ]:
2933399090

异烟腙合成路线

详细合成路线

异烟腙上下游产品

异烟腙上游产品

异烟腙下游产品

异烟腙海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

异烟腙