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9－羟基利培酮

9－羟基利培酮用途

Paliperidone (9-hydroxyrisperidone)是多巴胺受体抑拮抗剂。

9－羟基利培酮名称

[ CAS 号 ]:
144598-75-4

[ 中文名 ]:
帕潘立酮

[ 英文名 ]:
Paliperidone

[中文别名 ]:

[英文别名 ]:

UNII:838F01T721
9-OH-risperidone
9-Hydroxyrisperidone
Paliperidone
MFCD00871802

9－羟基利培酮生物活性

[ 描述 ]:

Paliperidone (9-hydroxyrisperidone)是多巴胺受体抑拮抗剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

[参考文献]

[1]. Peng L, et al. Paliperidone protects prefrontal cortical neurons from damages caused by MK-801 via Akt1/GSK3β signaling pathway. Schizophr Res. 2013 Jun;147(1):14-23.

[2]. Yang MC, et al. Neuroprotection of paliperidone on SH-SY5Y cells against β-amyloid peptide(25-35), N-methyl-4-phenylpyridinium ion, and hydrogen peroxide-induced cell death. Psychopharmacology (Berl). 2011 Oct;217(3):397-410.

[3]. Kalman S, et al. 9-hydroxy-risperidone (9OHRIS) prevents stress-induced β-actin overexpression in rat hippocampus. Neuropsychopharmacol Hung. 2010 Sep;12(3):425-31.

[相关活性小分子]

9－羟基利培酮物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
612.3±65.0 °C at 760 mmHg

[ 熔点 ]:
158-160°C

[ 分子式 ]:
C₂₃H₂₇FN₄O₃

[ 分子量 ]:
426.484

[ 闪点 ]:
324.1±34.3 °C

[ 精确质量 ]:
426.206726

[ PSA ]:
84.39000

[ LogP ]:
1.52

[ 外观性状 ]:
灰白色至淡橙色固体

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.692

[ 储存条件 ]:
Room temp

9－羟基利培酮MSDS

9－羟基利培酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV1164720

CHEMICAL NAME :: 4H-Pyrido(2,1-a)pyrimidin-4-one, 6,7,8,9-tetrahydro-3-(2-(4-(6-fluro-1,2-benzisoxazol- 3-yl)-1-piperidinyl)e thyl)-9-hydroxy-2-methyl-

CAS REGISTRY NUMBER :: 144598-75-4

LAST UPDATED :: 199509

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H27-F-N4-O3

MOLECULAR WEIGHT :: 426.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 33,399,1994

9－羟基利培酮安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
S45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ RTECS号 ]:
UV1164720

9－羟基利培酮合成路线

9－羟基利培酮上下游产品

9－羟基利培酮上游产品

9－羟基利培酮下游产品

9－羟基利培酮文献

Simple and sensitive screening and quantitative determination of 88 psychoactive drugs and their metabolites in blood through LC–MS/MS: Application on postmortem samples

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 970 , 1-7, (2014)

• The introduction has been modified. • More references have been added to the text. • Limitations of the method have been discussed more in detail.

The use of dried blood spots for quantification of 15 antipsychotics and 7 metabolites with ultra-high performance liquid chromatography - tandem mass spectrometry.

Drug Test. Anal. 7 , 502-11, (2015)

Therapeutic drug monitoring of antipsychotics is important in optimizing individual therapy. In psychiatric populations, classical venous blood sampling is experienced as frightening. Interest in alte...

Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma.

Mol. Med. Report. 12 , 6501-8, (2015)

Cyclin-dependent kinase 2 (CDK2) has been reported to be overexpressed in human colorectal cancer; it is responsible for the G1‑to‑S‑phase transition in the cell cycle and its deregulation is a hallma...

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