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盐酸左旋多巴甲酯

盐酸左旋多巴甲酯用途

Melevodopa hydrochloride is a biochemical.

盐酸左旋多巴甲酯名称

[ CAS 号 ]:
1421-65-4

[ 中文名 ]:
L-3,4-二羟基苯基丙氨酸甲酯盐酸

[ 英文名 ]:
L-3,4-Dihydroxyphenylalanine Methyl ester hydrochloride

[中文别名 ]:

盐酸左旋多巴甲酯

[英文别名 ]:

MFCD00038958
Methyl 3-hydroxy-L-tyrosinate hydrochloride (1:1)
Methyl L-DOPA hydrochloride
methyldopa hydrochloride

盐酸左旋多巴甲酯物理化学性质

[ 密度 ]:
1.322g/cm3

[ 沸点 ]:
384.4ºC at 760mmHg

[ 分子式 ]:
C₁₀H₁₄ClNO₄

[ 分子量 ]:
247.676

[ 闪点 ]:
186.3ºC

[ 精确质量 ]:
247.061142

[ PSA ]:
92.78000

[ LogP ]:
1.64290

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
1.86E-06mmHg at 25°C

[ 储存条件 ]:
-20°C

盐酸左旋多巴甲酯安全信息

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2923900090

盐酸左旋多巴甲酯合成路线

详细合成路线

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盐酸左旋多巴甲酯海关

[ 海关编码 ]: 2923900090

[ 中文概述 ]:
2923900090 其他季铵盐及季铵碱。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

盐酸左旋多巴甲酯文献

Striatal astrocytes act as a reservoir for L-DOPA.

PLoS ONE 9(9) , e106362, (2014)

L-DOPA is therapeutically efficacious in patients with Parkinson's disease (PD), although dopamine (DA) neurons are severely degenerated. Since cortical astrocytes express neutral amino acid transport...

L-DOPA-induced dyskinesia in a rat model of Parkinson's disease is associated with the fluctuational release of norepinephrine in the sensorimotor striatum.

J. Neurosci. Res. 92(12) , 1733-45, (2014)

L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) is the most common complication of standard L-DOPA therapy for Parkinson's disease experienced by most parkinsonian patients. LID is asso...

Genome-wide microarray analysis identifies a potential role for striatal retrograde endocannabinoid signaling in the pathogenesis of experimental L-DOPA-induced dyskinesia.

Synapse 68(8) , 332-43, (2014)

l-3,4-Dihydroxyphenylalanine (L-DOPA) is the most widely used drug for the treatment of Parkinson's disease. Unfortunately, chronic administration of this dopamine precursor causes L-DOPA-induced dysk...

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