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己二酸哌嗪

己二酸哌嗪用途

Piperazine adipate 是一种有效的，广谱的广谱驱虫剂，可以抵抗哺乳动物中很多常见的寄生虫感染。

己二酸哌嗪名称

[ CAS 号 ]:
142-88-1

[ 中文名 ]:
己二酸哌嗪

[ 英文名 ]:
Piperazine adipate

[中文别名 ]:

哌嗪己二酸盐

[英文别名 ]:

PIPERAZINE ADIPATE
hexanedioic acid,piperazine
EINECS 205-569-0
MFCD00050650

己二酸哌嗪生物活性

[ 描述 ]:

Piperazine adipate 是一种有效的,广谱的广谱驱虫剂,可以抵抗哺乳动物中很多常见的寄生虫感染。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 感染

[体外研究]

己二酸哌嗪(10mM)在暴露最多30分钟后引起A. galli和H. gallinae的死亡,抑制苹果酸盐氧化78％,并抑制两种寄生虫中的醛缩酶活性。己二酸哌嗪(10mM)也抑制了Ascaridia galli(A。galli)中的胆碱酯酶活性96％和Heterakis gallinae(H. gallinae)中的93％。己二酸哌嗪抑制草酸乙酯在A. galli和H. gallinae中的减少26％和55％[1]。

[参考文献]

[1]. Sharma RK, et al. Effect of parbendazole and piperazine adipate on the activity of some enzymes of Ascaridia galli and Heterakis gallinae. Vet Parasitol. 1987 May;24(3-4):211-20.

[相关活性小分子]

己二酸哌嗪物理化学性质

[ 沸点 ]:
338.5ºC at 760 mmHg

[ 熔点 ]:
250ºC (Decomposes)

[ 分子式 ]:
C₁₀H₂₀N₂O₄

[ 分子量 ]:
232.27700

[ 闪点 ]:
172.7ºC

[ 精确质量 ]:
232.14200

[ PSA ]:
98.66000

[ LogP ]:
0.55280

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
1.81E-05mmHg at 25°C

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents. May be light-sensitive.

己二酸哌嗪MSDS

详细MSDS(安全技术说明书)

己二酸哌嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MO1955000

CAS REGISTRY NUMBER :: 142-88-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C6-H10-O4.C4-H10-N2

MOLECULAR WEIGHT :: 232.32

WISWESSER LINE NOTATION :: T6N DNTJ &QV4VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 13,539,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,100,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1640 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,100,1982

己二酸哌嗪安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
MO1955000

[ 海关编码 ]:
2933599090

己二酸哌嗪海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

己二酸哌嗪文献

The effect of piperazine adipate and parbendazole on the carbohydrate metabolism of Ascaridia galli and Heterakis gallinae.

Angew. Parasitol. 28(4) , 207-10, (1987)

Carbohydrate metabolism of Ascardia galli and Heterakis gallinae was studied after their exposure in vitro to 10(-2) to 10(-5) M piperazine adipate and parbendazole for 10 to 60 min. Following treatme...

[Study of compounds with potential antiparasitic effect. V. Antihistaminics].

Wiad. Parazytol. 26(1) , 59-64, (1980)

[Experience with the prevention of enterobiasis in children from preschool institutions of the Zhitomir district].

Pediatriia (7) , 82-3, (1990)

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