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罗丹宁

罗丹宁用途

【用途一】
检定和重量分析测定银。有机合成，制造苯丙氨酸。

罗丹宁名称

[ CAS 号 ]:
141-84-4

[ 中文名 ]:
罗丹宁

[ 英文名 ]:
Rhodanine

[中文别名 ]:

[英文别名 ]:

Rhodanine
4-oxo-2-thioxo thiazolidine
4-Thiazolidinone,2-thioxo
Rhodaninic acid
2-Thioxo-4-thiazolidinone
Rhodanic acid
4-Thiazolidinone, 2-thioxo-
2-Thioxo-1,3-thiazolidin-4-one
2-Sulfanyl-1,3-thiazol-4(5H)-one
4-Oxo-2-thioxothiazoline

罗丹宁物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
218.2ºC at 760mmHg

[ 熔点 ]:
165-169 °C(lit.)

[ 分子式 ]:
C₃H₃NOS₂

[ 分子量 ]:
133.192

[ 闪点 ]:
85.7ºC

[ 精确质量 ]:
132.965607

[ PSA ]:
86.49000

[ LogP ]:
0.06

[ 外观性状 ]:
黑色吸湿的晶体

[ 蒸汽压 ]:
0.128mmHg at 25°C

[ 折射率 ]:
1.712

[ 储存条件 ]:
-20°C

[ 水溶解性 ]:
SOLUBLE IN HOT WATER

罗丹宁MSDS

罗丹宁毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VI7700000

CHEMICAL NAME :: Rhodanine

CAS REGISTRY NUMBER :: 141-84-4

LAST UPDATED :: 199701

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C3-H3-N-O-S2

MOLECULAR WEIGHT :: 133.19

WISWESSER LINE NOTATION :: T5SYMV EHJ BUS

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1093,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1093,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1093,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.3- 1930- Volume(issue)/page/year: 17(1),36,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 12,447,1904

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04798

罗丹宁安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H318

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R41

[ 安全声明 (欧洲) ]:
S22-S26-S39

[ 危险品运输编码 ]:
3288

[ WGK德国 ]:
3

[ RTECS号 ]:
VI7700000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
29341000

罗丹宁合成路线

罗丹宁上下游产品

罗丹宁上游产品

罗丹宁下游产品

罗丹宁海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

罗丹宁文献

Biochemical and histopathological evidence on the beneficial effects of Tragopogon graminifolius in TNBS-induced colitis.

Pharm. Biol. 53(3) , 429-36, (2015)

Tragopogon graminifolius DC. (Compositae) (TG) has been proposed as an efficacious remedy for gastrointestinal ulcers in Iranian traditional medicine.The present study evaluates the efficacy of TG on ...

Acidified bile acids increase hTERT expression via c-myc activation in human gastric cancer cells.

Oncol. Rep. 33 , 3038-44, (2015)

Human telomerase reverse transcriptase (hTERT) is upregulated in most cancer cell types as well in immortalized cells. The underlying mechanism for such upregulation, however, remains largely unknown....

Disruption of copper-dependent signaling pathway in the nitrofen-induced congenital diaphragmatic hernia.

Pediatr. Surg. Int. 31(1) , 31-5, (2015)

Normal development of the fetal diaphragm requires muscularization of the diaphragm as well as the structural integrity of its underlying connective tissue components. Developmental mutations that inh...

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罗丹宁