寡霉素

寡霉素用途

寡霉素是由链霉菌属产生的大环内酯类化合物,通过其抑制线粒体膜结合ATP合成酶的能力,对其他生物体具有毒性。线粒体F1FO-ATP合成酶可在缺血期间转换为ATP水解酶,因此,在这些条件下,寡粘菌素的抑制将减少ATP的消耗,而不是阻碍ATP的合成。

寡霉素名称

[ CAS 号 ]:
1404-19-9

[ 中文名 ]:
寡霉素

[ 英文名 ]:
Oligomycin

[英文别名 ]:

Oligomycin From Streptomyces Diastatochromogenes
EINECS 215-767-9
MFCD00065705

寡霉素生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 抗感染 >> 真菌

信号通路 >> 跨膜转运 >> ATP合成酶

寡霉素物理化学性质

[ 密度 ]:
1.14 g/cm3

[ 沸点 ]:
886.3ºC at 760 mmHg

[ 熔点 ]:
84-100ºC

[ 分子式 ]:
C₁₃₅H₂₂₀O₃₃

[ 分子量 ]:
2371.171

[ 闪点 ]:
252ºC

[ 精确质量 ]:
2369.553711

[ PSA ]:
536.99000

[ LogP ]:
17.71190

[ 外观性状 ]:
灰白色至白色粉末

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.543

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
Sparingly soluble in water. Soluble in DMSO (20mg/ml) and ethanol (30mg/ml) /n

寡霉素MSDS

详细MSDS(安全技术说明书)

寡霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RK3325000

CHEMICAL NAME :: Oligomycin

CAS REGISTRY NUMBER :: 1404-19-9

LAST UPDATED :: 199012

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70- Volume(issue)/page/year: 15,660,1984

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 4,962,1954

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 4,962,1954

寡霉素安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
UN 2811

[ WGK德国 ]:
3

[ RTECS号 ]:
RK3325000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

寡霉素文献

Thermogenic activity of UCP1 in human white fat-derived beige adipocytes.

Mol. Endocrinol. 29(1) , 130-9, (2014)

Heat-producing beige/brite (brown-in-white) adipocytes in white adipose tissue have the potential to suppress metabolic disease in mice and hold great promise for the treatment of obesity and type 2 d...

Mitochondrial function provides instructive signals for activation-induced B-cell fates.

Nat. Commun. 6 , 6750, (2015)

During immune reactions, functionally distinct B-cell subsets are generated by stochastic processes, including class-switch recombination (CSR) and plasma cell differentiation (PCD). In this study, we...

Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells.

Sci. Rep. 5 , 16895, (2015)

Mechanical cues direct the lineage commitment of mesenchymal stem cells (MSCs). In this study, we identified the operative molecular mechanisms through which dynamic tensile loading (DL) regulates cha...

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寡霉素