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N,N-二甲基-4-亚硝基苯胺

N,N-二甲基-4-亚硝基苯胺用途

【用途一】
测定二氧化碳时用以吸收氯化氢，苯基葡萄糖的沉淀剂，测定氯化氢、钯和高氯酸盐，分光光度测定铱、钯、铂和铑。

N,N-二甲基-4-亚硝基苯胺名称

[ CAS 号 ]:
138-89-6

[ 中文名 ]:
N,N-二甲基-4-亚硝基苯胺

[ 英文名 ]:
N,N-Dimethyl-4-nitrosoaniline

[中文别名 ]:

[英文别名 ]:

EINECS 205-343-1
p-nitrosodimethyl aniline
p-dimethylaminonitrosobenzene
p-Nitrosodimethylanilide
4-nitroso-N,N-di-methylaniline
MFCD00002063
N,N-dimethyl-p-nitrosoaniline
Paranitrosodimethylanilide
Benzenamine, N,N-dimethyl-4-nitroso-
p-Nitroso-N,N-dimethylaniline

N,N-二甲基-4-亚硝基苯胺物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
258.7±23.0 °C at 760 mmHg

[ 熔点 ]:
85-87 °C(lit.)

[ 分子式 ]:
C₈H₁₀N₂O

[ 分子量 ]:
150.178

[ 闪点 ]:
110.3±22.6 °C

[ 精确质量 ]:
150.079315

[ PSA ]:
32.67000

[ LogP ]:
2.02

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.529

[ 储存条件 ]:
库房通风低温干燥,与酸分开存放

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, strong reducing agents, strong acids, acetic acid, acetic anhydride. Highly flammable (?)

N,N-二甲基-4-亚硝基苯胺MSDS

N,N-二甲基-4-亚硝基苯胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BX7175000

CHEMICAL NAME :: Aniline, N,N-dimethyl-p-nitroso-

CAS REGISTRY NUMBER :: 138-89-6

BEILSTEIN REFERENCE NO. :: 0607293

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H10-N2-O

MOLECULAR WEIGHT :: 150.20

WISWESSER LINE NOTATION :: ONR DN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - hematuria

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7300 mg/kg/1Y-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Blood - lymphoma, including Hodgkin's disease

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 10 ug/plate

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 8(Suppl 7),1,1986

N,N-二甲基-4-亚硝基苯胺安全信息

[ 符号 ]:

GHS02, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H251-H301-H315-H317-H319-H335

[ 警示性声明 ]:
P235 + P410-P261-P280-P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
F:Highlyflammable;T:Toxic;

[ 风险声明 (欧洲) ]:
R23/24/25;R33;R8

[ 安全声明 (欧洲) ]:
S16-S26-S36/37-S45

[ 危险品运输编码 ]:
UN 1369 4.2/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
BX7175000

[ 包装等级 ]:
II

[ 危险类别 ]:
4.2

[ 海关编码 ]:
2921430090

N,N-二甲基-4-亚硝基苯胺合成路线

N,N-二甲基-4-亚硝基苯胺制备

1.将30g二甲基苯胺溶于100ml浓盐酸，在冰盐浴中冷却，搅拌下缓缓滴加含18g亚硝酸钠的50ml水溶液，保持反应液温度为0-5℃。加毕，继续搅拌半小时。吸滤，滤饼用水洗涤，真空干燥，得成品。

N,N-二甲基-4-亚硝基苯胺海关

[ 海关编码 ]: 2921430090

[ 中文概述 ]:
2921430090 甲苯胺及其衍生物以及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 原产地证据文件及编号(例附原产地证书, 原产于欧盟的

[ Summary ]:
HS:2921430090 toluidines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

N,N-二甲基-4-亚硝基苯胺文献

Role of type I & type II radicals in DNA damage and activation of Caspase 3 via mitochondrial pathway induced by photosensitized benzophenone

Toxicol. Lett. 235(2) , 84-95, (2015)

[Display omitted]

Non-animal photosafety screening for complex cosmetic ingredients with photochemical and photobiochemical assessment tools.

Regul Toxicol Pharmacol 72 , 578-85, (2015)

Previously, a non-animal screening approach was proposed for evaluating photosafety of cosmetic ingredients by means of in vitro photochemical and photobiochemical assays; however, complex cosmetic in...

Phototoxic Risk Assessments on Benzophenone Derivatives: Photobiochemical Assessments and Dermal Cassette-Dosing Pharmacokinetic Study.

J. Pharmacol. Exp. Ther. 354 , 195-202, (2015)

This study aimed to qualify photosafety screening on the basis of photochemical and pharmacokinetic (PK) data on dermally applied chemicals. Six benzophenone derivatives (BZPs) were selected as model ...

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