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去甲肾上腺素

去甲肾上腺素用途

生化研究。医药

去甲肾上腺素名称

[ CAS 号 ]:
138-65-8

[ 中文名 ]:
DL-去甲肾上腺素

[ 英文名 ]:
Norepinephrine

[中文别名 ]:

[英文别名 ]:

1-(3,4-Dihydroxy)phenyl-2-aminoethanol
(-)-NORADRENALINE
4-[(1R)-2-amino-1-hydroxyéthyl]benzène-1,2-diol
L-NOREPINEPHRINE
(+)-Norepinephrin
4-((R)-2-Amino-1-hydroxy-ethyl)-benzene-1,2-diol
1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]-
(R)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol
EINECS 205-337-9
4-(1-Hydroxy-2-aminoethyl)catechol

去甲肾上腺素物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
442.6±40.0 °C at 760 mmHg

[ 熔点 ]:
-190ºC (dec.)

[ 分子式 ]:
C₈H₁₁NO₃

[ 分子量 ]:
169.178

[ 闪点 ]:
221.5±27.3 °C

[ 精确质量 ]:
169.073898

[ PSA ]:
86.71000

[ LogP ]:
-0.88

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.659

[ 储存条件 ]:
室温

去甲肾上腺素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DN6300000

CHEMICAL NAME :: Benzyl alcohol, alpha-(aminomethyl)-3,4-dihydroxy-, (+-)-

CAS REGISTRY NUMBER :: 138-65-8

LAST UPDATED :: 199106

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C8-H11-N-O3

MOLECULAR WEIGHT :: 169.20

WISWESSER LINE NOTATION :: Z1YQR CQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 68,501,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 130 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 95,502,1949

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 68,501,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,64,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4700 ug/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 95,502,1949

去甲肾上腺素安全信息

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
R28

[ 安全声明 (欧洲) ]:
S28;S45;S36/S37/S39

[ WGK德国 ]:
3

[ RTECS号 ]:
DN6300000

[ 海关编码 ]:
2922509090

去甲肾上腺素合成路线

详细合成路线

去甲肾上腺素上下游产品

去甲肾上腺素上游产品

去甲肾上腺素下游产品

去甲肾上腺素海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%