多巴胺

多巴胺用途

用于各种类型休克，包括中毒性休克丶心源性休克、出血性休克、中枢性休克、特别对伴有肾功能不全、心排出量降低、周围血管阻力较低并且已补足血容量的病人更有意义。DARPP-32基因有三种变体：TT TC CC,这些变体决定大脑中多巴胺的水平。

多巴胺作用

本品为体内合成肾上腺素的前体，具有激动β受体作用，也有一定的α受体激动作用。能增强心肌收缩力，增加心排血量，加快心率作用较轻微，对周围血管有轻度收缩作用，升高动脉压，对内脏血管(肾、肠系膜、冠状动脉)则使之扩张，增加血流量，使肾血流量及肾小球滤过均增加，从而使尿量及钠排泄量增多。

多巴胺名称

[ CAS 号 ]:
51-61-6

[ 中文名 ]:
2-(3,4-二羟基苯基)乙胺

[ 英文名 ]:
dopamine

[中文别名 ]:

多巴胺

[英文别名 ]:

3,4-Dihydroxy-b-phenethylamine Hydrochloride
4-(2-aminoethyl)benzene-1,2-diol
1,2-Benzenediol, 4-(2-aminoethyl)-
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-aminoéthyl)benzène-1,2-diol chlorhydrate
b-(3,4-Dihydroxyphenyl)ethylamine Hydrochloride
Tensamin
α-(3,4-Dihydroxyphenyl)-β-aminoethane
Rascordin
Pyrocatechol, 4- (2-aminoethyl)-, hydrochloride

多巴胺物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
337.7±27.0 °C at 760 mmHg

[ 熔点 ]:
218-220ºC

[ 分子式 ]:
C₈H₁₁NO₂

[ 分子量 ]:
153.18

[ 闪点 ]:
158.0±23.7 °C

[ PSA ]:
66.48000

[ LogP ]:
0.12

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.619

[ 储存条件 ]:
库房低温,通风,干燥

多巴胺MSDS

详细MSDS(安全技术说明书)

多巴胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX1088000

CHEMICAL NAME :: Pyrocatechol, 4-(2-aminoethyl)-

CAS REGISTRY NUMBER :: 51-61-6

LAST UPDATED :: 199806

DATA ITEMS CITED :: 21

MOLECULAR FORMULA :: C8-H11-N-O2

MOLECULAR WEIGHT :: 153.20

WISWESSER LINE NOTATION :: Z2R CQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 163 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - dehydration

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 950 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - respiratory stimulation Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 59 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - respiratory stimulation Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracervical

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 74 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1120 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9 gm/kg/30D-C

TOXIC EFFECTS :: Blood - normocytic anemia Blood - changes in spleen Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10920 mg/kg/26W-I

TOXIC EFFECTS :: Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 120 ug/kg

SEX/DURATION :: lactating female 2 hour(s) post-birth

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 70 mg/kg

SEX/DURATION :: female 1-7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - other postnatal measures or effects

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 300 mg/kg

SEX/DURATION :: female 30 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 100 mg/kg

SEX/DURATION :: female 10-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - other postnatal measures or effects

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 100 mg/kg

SEX/DURATION :: female 10-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - eye/ear

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 70 mg/kg

SEX/DURATION :: female 1-7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - other postnatal measures or effects

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 1 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,9,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3655 No. of Facilities: 50 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 8422 (estimated) No. of Female Employees: 7695 (estimated)

多巴胺

多巴胺用途

多巴胺作用

多巴胺名称

多巴胺物理化学性质

多巴胺MSDS

详细MSDS(安全技术说明书)

多巴胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

多巴胺合成路线

详细合成路线

多巴胺上下游产品

多巴胺上游产品

多巴胺下游产品

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