D-甲状腺素
D-甲状腺素用途
D-甲状腺素(钠)(D-T4(钠))是甲状腺激素的左旋异构体,可用于研究甲状腺功能异常[1][2]。
D-甲状腺素名称
[ CAS 号 ]:
137-53-1
[ 中文名 ]:
D-甲状腺素
[ 英文名 ]:
D-THYROXINE SODIUM SALT
[中文别名 ]:
[英文别名 ]:
- detyroxin
- biotirmone
- Travenon
- EINECS 205-301-2
- dextroxin
- lisolipin
- choloxin
- dextroid
- dynothel
- Eulipos
D-甲状腺素生物活性
[ 描述 ]:
D-甲状腺素(钠)(D-T4(钠))是甲状腺激素的左旋异构体,可用于研究甲状腺功能异常[1][2]。
[ 相关类别 ]:
[体外研究]
D-甲状腺素(钠)(D-T4(钠))也影响双羟基香豆素的药理作用[2]。
[体内研究]
D-甲状腺素(钠)(D-T4(钠))抑制小鼠体内双羟基香豆素以及哌替啶和戊巴比妥的代谢[1]。
[参考文献]
D-甲状腺素物理化学性质
[ 沸点 ]:
576.3ºC at 760mmHg
[ 分子式 ]:
C15H10I4NNaO4
[ 分子量 ]:
798.85200
[ 闪点 ]:
302.3ºC
[ 精确质量 ]:
798.66900
[ PSA ]:
95.61000
[ LogP ]:
3.92290
[ 蒸汽压 ]:
4.02E-14mmHg at 25°C
D-甲状腺素毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XP3582990
- CHEMICAL NAME :
- Thyroxine, monosodium salt, D-
- CAS REGISTRY NUMBER :
- 137-53-1
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C15-H10-I4-N-O4.Na
- MOLECULAR WEIGHT :
- 798.85
- WISWESSER LINE NOTATION :
- QR BI FI DOR BI FI D1YZVO &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 12 ug/kg/12D-I
- TOXIC EFFECTS :
- Liver - hepatitis (hepatocellular necrosis), diffuse Liver - liver function tests impaired Nutritional and Gross Metabolic - body temperature increase
- REFERENCE :
- JJMDAT Japanese Journal of Medicine. (Nankodo Co., Ltd., POB 5272, Tokyo International 100-31, Japan) V.1-30, 1962-1991. For publisher information, see IEDIEP. Volume(issue)/page/year: 23,282,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1500 mg/kg/30D-C
- TOXIC EFFECTS :
- Vascular - BP elevation not characterized in autonomic section Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- REFERENCE :
- TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 29,207,1970
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 222 mg/kg/24W-C
- TOXIC EFFECTS :
- Vascular - BP elevation not characterized in autonomic section Kidney, Ureter, Bladder - changes in bladder weight Endocrine - evidence of thyroid hyperfunction
- REFERENCE :
- TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 29,565,1970 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 29 mg/kg
- SEX/DURATION :
- female 1-29 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 32,1182,1971
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 15 mg/kg
- SEX/DURATION :
- female 15-29 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - physical
- REFERENCE :
- DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 32,1182,1971
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 16 mg/kg
- SEX/DURATION :
- female 16-31 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
- REFERENCE :
- SDMEAL South Dakota Journal of Medicine. (South Dakota Medical Assoc., 608 West Ave. N, Sioux Falls, SD 57104) V.18- 1965- Volume(issue)/page/year: 21,33,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5407 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 63 (estimated) No. of Female Employees: 9 (estimated)
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相关化合物
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