2-氰基丙烯酸甲酯

DATA ITEMS CITED :

28

MOLECULAR FORMULA :

C5-H5-N-O2

MOLECULAR WEIGHT :

111.11

WISWESSER LINE NOTATION :

1UYCN&VO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Human

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1600 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

101 ppm/6H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

>10959 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intratesticular

DOSE :

100 mg/kg

SEX/DURATION :

male 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

MUTATION DATA

TYPE OF TEST :

Mutation in microorganisms

TEST SYSTEM :

Bacteria - Salmonella typhimurium

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 188,97,1987 *** REVIEWS *** ACGIH TLV-STEL 18 mg/m3 (4 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 9.1 mg/m3 (2 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 2 ppm (8 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,162,1971 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 2 ppm (8 mg/m3);STEL 4 ppm (16 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 2 ppm (8 mg/m3) JAN 1993 OEL-BELGIUM:TWA 2 ppm (9.1 mg/m3);STEL 4 ppm (18 mg/m3) JAN 1993 OEL-DENMARK:TWA 2 ppm (8 mg/m3) JAN 1993 OEL-FINLAND:TWA 2 ppm (9 mg/m3);STEL 4 ppm (18 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 2 ppm (8 mg/m3);STEL 4 ppm (16 mg/m3) JAN 1993 OEL-GERMANY:TWA 2 ppm (8 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 2 ppm (8 mg/m3) JAN 1993 OEL-SWEDEN:TWA 2 ppm (9 mg/m3);STEL 4 ppm (18 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (9 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 2 ppm (8 mg/m3);STEL 4 ppm (16 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHYL 2-CYANOACRYLATE-air:10H TWA 2 ppm;STEL 4 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4755 No. of Facilities: 895 (estimated) No. of Industries: 25 No. of Occupations: 25 No. of Employees: 18406 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4755 No. of Facilities: 1434 (estimated) No. of Industries: 46 No. of Occupations: 51 No. of Employees: 51367 (estimated) No. of Female Employees: 22918 (estimated)