阿考烟肼

阿考烟肼用途

Aconiazide(Isonicophen) 是一种口服活性的异烟肼衍生物,可用于结核病的研究。

阿考烟肼名称

[ CAS 号 ]:
13410-86-1

[ 中文名 ]:
阿考烟肼

[ 英文名 ]:
Aconiazide

[英文别名 ]:

Isonicophen
Aconiazid
Phenoxalid
ACONIAZIDE

阿考烟肼生物活性

[ 描述 ]:

Aconiazide(Isonicophen) 是一种口服活性的异烟肼衍生物,可用于结核病的研究。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

[参考文献]

[1]. KENNETH L. DOOLEY, et al. Fourteen-Day , Repeat-Dose Toxicity Evaluation of Aconiazide _- Administered Orally to Male and Female Fischer 344 Rats. JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY Vdume 12, Number 4, 1993

阿考烟肼物理化学性质

[ 密度 ]:
1.3g/cm3

[ 分子式 ]:
C₁₅H₁₃N₃O₄

[ 分子量 ]:
299.28100

[ 精确质量 ]:
299.09100

[ PSA ]:
100.88000

[ LogP ]:
1.69980

[ 折射率 ]:
1.61

阿考烟肼毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US5638000

CHEMICAL NAME :: 4-Pyridinecarboxylic acid, ((2-(carboxymethoxy)phenyl)methylene)hydrazide

CAS REGISTRY NUMBER :: 13410-86-1

BEILSTEIN REFERENCE NO. :: 0300804

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H13-N3-O4

MOLECULAR WEIGHT :: 299.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7 gm/kg/14D-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - structural change in nerve or sheath Liver - fatty liver degeneration Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 12,329,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 36400 mg/kg/26W-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - structural change in nerve or sheath Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 14,328,1995

阿考烟肼安全信息

[ 海关编码 ]:
2933399090

阿考烟肼海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%