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五水β-甘油磷酸钠

五水β-甘油磷酸钠用途

β-Glycerol phosphate disodium salt pentahydrate 是磷酸酶和张力蛋白同源物 (PTEN) 的抑制剂,来自专利US 20110002877 A1。

五水β-甘油磷酸钠名称

[ CAS 号 ]:
13408-09-8

[ 中文名 ]:
B-甘油磷酸钠五水合物

[ 英文名 ]:
β-Glycerol phosphate disodium salt pentahydrate

[中文别名 ]:

[英文别名 ]:

Disodium 1,3-dihydroxypropan-2-yl phosphate
beta-Glycerophosphoric acid
Sodium 1,3-dihydroxypropan-2-yl phosphate
sodium glycerol 2-phosphate
MFCD00149083
Disodium 1,3-dihydroxy-2-propanyl phosphate
EINECS 212-464-3
Disodium β-Glycerophosphate Pentahydrate
β-Glycerol phosphate disodium salt pentahydrate

五水β-甘油磷酸钠生物活性

[ 描述 ]:

β-Glycerol phosphate disodium salt pentahydrate 是磷酸酶和张力蛋白同源物 (PTEN) 的抑制剂,来自专利US 20110002877 A1。

[ 相关类别 ]:

信号通路 >> PI3K/Akt/mTOR 信号通路 >> PTEN

研究领域 >> 癌症

研究领域 >> 神经疾病

[ 靶点 ]

Phosphatase and tensin homolog (PTEN)[1]

[参考文献]

[1]. Hongbo R. Luo, et al. PTEN Inhibitors Treat Neutropenia-Associated Pneumonia. US 20110002877 A1.

[相关活性小分子]

VO-OHPIC 三水合物 | SF1670

五水β-甘油磷酸钠物理化学性质

[ 沸点 ]:
488.2ºC at 760mmHg

[ 熔点 ]:
>300ºC

[ 分子式 ]:
C₃H₁₉Na₂O₁₁P

[ 分子量 ]:
308.13

[ 闪点 ]:
249.1ºC

[ PSA ]:
111.69000

[ LogP ]:
0.28450

[ 外观性状 ]:
固体;White powder to crystal

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: 0.1 g/mL, clear, colorless | Soluble in water.

五水β-甘油磷酸钠MSDS

五水β-甘油磷酸钠安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UA0600000

[ 海关编码 ]:
2919900090

五水β-甘油磷酸钠合成路线

五水β-甘油磷酸钠海关

[ 海关编码 ]: 2919900090

[ 中文概述 ]:
HS:2919900090 其他磷酸酯及其盐（包括乳磷酸盐）（包括它们的卤化，磺化，硝化和亚硝化衍生物）增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2919900090 other phosphoric esters and their salts, including lactophosphates; their halogenated, sulphonated, nitrated or nitrosated derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

五水β-甘油磷酸钠文献

P7170, a novel inhibitor of mTORC1/mTORC2 and Activin receptor-like Kinase 1 (ALK1) inhibits the growth of non small cell lung cancer.

Mol. Cancer 13 , 259, (2014)

Lung cancer is the major cause of cancer-related deaths and many cases of Non Small Cell Lung Cancer (NSCLC), a common type of lung cancer, have frequent genetic/oncogenic activation of EGFR, KRAS, PI...

Polyubiquitin chain-dependent protein degradation in TRIM30 cytoplasmic bodies.

Exp. Mol. Med. 47 , e159, (2015)

Viral infection induces numerous tripartite motif (TRIM) proteins to control antiviral immune signaling and viral replication. Particularly, SPRY-containing TRIM proteins are found only in vertebrates...

Human mesenchymal stem cells as a novel platform for simultaneous evaluation of cytotoxicity and genotoxicity of pharmaceuticals.

Mutagenesis 30 , 391-9, (2015)

The in vitro micronucleus test is a well-known test for the screening of genotoxic compounds. However until now, most studies have been performed on either human peripheral lymphocytes or established ...

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