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盐酸洛贝林

盐酸洛贝林用途

Lobeline盐酸盐是烟碱样受体激动剂, 作为有效的神经元烟碱受体α3β2和α4β2拮抗剂。

盐酸洛贝林名称

[ CAS 号 ]:
134-63-4

[ 中文名 ]:
盐酸山梗碱

[ 英文名 ]:
α-Lobeline Hydrochcloride

[中文别名 ]:

[英文别名 ]:

Lobelin hydrochloride
Lobeline hydrochloride
EINECS 205-150-2
MFCD00082455
α-Lobeline hydrochloride
(-)-Lobeline hydrochloride
Lobeline (hydrochloride)

盐酸洛贝林生物活性

[ 描述 ]:

Lobeline盐酸盐是烟碱样受体激动剂, 作为有效的神经元烟碱受体α3β2和α4β2拮抗剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 胆碱受体

信号通路 >> 神经信号通路 >> 胆碱受体

研究领域 >> 神经疾病

天然产物 >> 生物碱

[相关活性小分子]

盐酸洛贝林物理化学性质

[ 沸点 ]:
485.6ºC at 760mmHg

[ 熔点 ]:
183-185 °C (dec.)(lit.)

[ 分子式 ]:
C₂₂H₂₈ClNO₂

[ 分子量 ]:
373.916

[ 闪点 ]:
247.5ºC

[ 精确质量 ]:
373.180847

[ PSA ]:
40.54000

[ LogP ]:
4.97590

[ 外观性状 ]:
白色至灰白色固体

[ 蒸汽压 ]:
3.02E-11mmHg at 25°C

[ 折射率 ]:
-57.5 ° (C=1, H2O)

[ 储存条件 ]:
Store at RT

[ 水溶解性 ]:
H2O: 25 mg/mL

盐酸洛贝林MSDS

盐酸洛贝林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OJ8490100

CHEMICAL NAME :: Lobeline, hydrochloride

CAS REGISTRY NUMBER :: 134-63-4

LAST UPDATED :: 198706

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C22-H27-N-O2.Cl-H

MOLECULAR WEIGHT :: 373.96

WISWESSER LINE NOTATION :: T6NTJ A1 B1YQR& F1VR &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 39900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,913,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 87500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,913,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,913,1982

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 163,279,1931

盐酸洛贝林安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H331

[ 警示性声明 ]:
P261-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R23/25

[ 安全声明 (欧洲) ]:
S36/37/39-S45

[ 危险品运输编码 ]:
UN 1544 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
OJ8490100

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

盐酸洛贝林合成路线

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盐酸洛贝林文献

Enhancing perception of contaminated food through acid-mediated modulation of taste neuron responses.

Curr. Biol. 24(17) , 1969-77, (2014)

Natural foods contain not only nutrients, but also nonnutritious and potentially harmful chemicals. Thus, animals need to evaluate food content in order to make adequate feeding decisions.Here, we inv...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

The effects of lobeline on nicotine withdrawal-induced depression-like behavior in mice.

Psychopharmacol. Ser. 231(15) , 2989-98, (2014)

Evidence suggests that neuronal nicotinic acetylcholine receptor (nAChR) ligand lobeline has antidepressant-like properties.The present study investigated the effects of lobeline on nicotine withdrawa...

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