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过氧化丁酮

过氧化丁酮用途

【用途一】
用作不饱和聚酯树脂的常温固化剂、有机合成的引发剂、漂白剂、杀菌剂
【用途二】
在聚酯及丙烯酸系聚合物生产中用作催化剂，是最安全的过氧化物。还广泛用于强化聚酯玻璃纤维生产作硬化剂。
【用途三】
不饱和聚酯树脂常温固化引发剂。

过氧化丁酮名称

[ CAS 号 ]:
1338-23-4

[ 中文名 ]:
2-过氧化丁酮

[ 英文名 ]:
Dioxydi-2,2-butanediyl dihydroperoxide

[中文别名 ]:

[英文别名 ]:

MFCD00042641
dioxydibutane-2,2-diyl dihydroperoxide
kayamekm
ketonox
Hydroperoxide, (dioxybis(1-methylpropylidene))bis-
mepox
mekp
Hi-Point 90 (in DMP)
kayameka
Dioxydi-2,2-butanediyl dihydroperoxide

过氧化丁酮物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
304.9±27.0 °C at 760 mmHg

[ 熔点 ]:
110°C

[ 分子式 ]:
C₈H₁₈O₆

[ 分子量 ]:
210.225

[ 闪点 ]:
138.2±23.7 °C

[ 精确质量 ]:
210.110336

[ PSA ]:
77.38000

[ LogP ]:
3.65

[ 外观性状 ]:
透明液体

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.454

[ 储存条件 ]:
库房通风低温,轻装轻卸,与有机物、还原剂、硫、磷易燃物,食品原料分开存放

[ 水溶解性 ]:
0.1-0.5 g/100 mL at 22 ºC

过氧化丁酮MSDS

详细MSDS(安全技术说明书)

过氧化丁酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EL9450000

CHEMICAL NAME :: 2-Butanone, peroxide

CAS REGISTRY NUMBER :: 1338-23-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 31

MOLECULAR FORMULA :: C8-H16-O4

MOLECULAR WEIGHT :: 176.24

WISWESSER LINE NOTATION :: 1V2OO2V1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of esophagus Gastrointestinal - nausea or vomiting Gastrointestinal - other changes

REFERENCE :: NCPBBY National Clearinghouse for Poison Control Centers, Bulletin. (U.S. Department of Health, Education, and Welfare, Washington, DC) Volume(issue)/page/year: Jan/Feb,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 484 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 ppm/4H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - ataxia

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 165,201,1957

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 170 ppm/4H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2033 mg/kg/7W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 273 mg/kg/7W-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 19,205,1958 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 282 mg/kg

REFERENCE :: RARSAM Radiation Research, Supplement. (New York, NY) No.1-7, 1959-67. Discontinued. Volume(issue)/page/year: 3,193,1963 *** REVIEWS *** ACGIH TLV-CL 1.5 mg/m3 (0.2 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-BELGIUM:STEL 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-DENMARK:STEL 1 mg/m3 JAN 1993 OEL-FINLAND:STEL 0.2 ppm (1.5 mg/m3);Skin JAN 1993 OEL-FRANCE:STEL 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-SWEDEN:STEL 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.2 ppm (1.5 mg/m3);STEL 0.2 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHYL ETHYL KETONE PEROXIDE-air:CL 0.2 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80105 No. of Facilities: 2226 (estimated) No. of Industries: 29 No. of Occupations: 31 No. of Employees: 20053 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80105 No. of Facilities: 1879 (estimated) No. of Industries: 23 No. of Occupations: 31 No. of Employees: 25827 (estimated) No. of Female Employees: 6514 (estimated)

过氧化丁酮安全信息

[ 符号 ]:

GHS02, GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H242-H314

[ 警示性声明 ]:
P220-P280-P305 + P351 + P338-P310-P410-P411 + P235

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
O:Oxidizingagent;C:Corrosive;

[ 风险声明 (欧洲) ]:
R7;R22;R34

[ 安全声明 (欧洲) ]:
S17-S26-S36/37/39-S45-S14-S53-S3/7-S47-S7

[ 危险品运输编码 ]:
UN 3105 5.2

[ WGK德国 ]:
1

[ 包装等级 ]:
II

[ 危险类别 ]:
5.2

[ 海关编码 ]:
2909600000

过氧化丁酮制备

1.在硫酸存在下，由甲乙酮与过氧化氢（双氧水）反应制取。经氧化、中和、分离、脱水、静置、过滤，最后加入增溶剂而得成品

2.由双氧水与丁酮制备MEKP是在酸性介质中进行的，反应按下列方式进行：

将双氧水和丁酮加入反应釜中[30%的过氧化氢与丁酮的摩尔比为(1.6～1.9)∶1]加入滴加量为H2O2质量25%的液体催化剂（磷酸，用量以总质量计为20%～30%）；边滴边搅拌，并控制温度在25℃左右，置入H2O2加料贮槽中备用。然后按同一摩尔比配好丁酮后置入丁酮加料贮槽中。在合成反应器中置入稀释剂二丁酯启动反应器搅拌器，同时向反应器中加入H2O和丁酮，加料时间需1h左右，反应温度为25℃以下，加料完毕后继续反应一段时间。反应后的产物经液液分离后，废催化剂排放，同时加入内稳定剂和碳酸钠，产品pH值调至5。再加干燥剂干燥至无色透明，过滤除去固体组分，常温下真空脱除残留的水分，即得合格产品。产品的活性氧可达11%，产品收率>95%。

3.制法：

于1L烧杯中加入丁酮（2）217g（3.0mol），冰水浴冷却下慢慢滴加30%的双氧水330g（3.0mol），控制反应液温度在20～25℃，加完后反应液为清亮溶液。于另一1L烧杯中加入30mL（10%）的盐酸，冰浴冷却，搅拌下慢慢加入上面的溶液，反应放热，注意控制加入速度，以使反应液温度在20～25℃之间。加完后再搅拌1h。加入100g氯化铵或硫酸铵，搅拌溶解，盐析出产品。分出有机层，无水硫酸钠干燥，过滤，得产品（1）240g，收率82%。

过氧化丁酮海关

[ 海关编码 ]: 2909600000

[ 中文概述 ]:
2909600000 过氧化醇、过氧化醚、过氧化酮及其卤化、磺化、硝化、亚硝化衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2909600000 alcohol peroxides, ether peroxides, ketone peroxides and their halogenated, sulphonated, nitrated or nitrosated derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

过氧化丁酮文献

[Chemical burns of the upper digestive tract and cytolytic hepatitis following ingestion of a mixture of methyl ethyl ketone peroxide, diacetone alcohol and diisobutyl phthalate].

J. Toxicol. Clin. Exp. 12(4-5) , 205-6, (1992)

Effect of dietary vitamin E on methyl ethyl ketone peroxide damage to microsomal cytochrome P-450 peroxidase.

Chem. Biol. Interact. 55(3) , 317-26, (1985)

The effect of dietary vitamin E on in vivo and in vitro damage by methyl ethyl ketone peroxide (MEKP) to cytochrome P-450 and its associated enzymatic activity was studied. In vivo, MEKP damaged micro...

Contact sensitivity to methyl ethyl ketone peroxide in a paint sprayer.

Contact Dermatitis 26(1) , 52-3, (1992)

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