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Autocamtide 2

Autocamtide 2用途

Autocamtide 2是钙/钙调蛋白依赖的蛋白激酶II (CaMKII)的高选择性肽底物。它可以用于测定CaMKII的活力。

Autocamtide 2名称

[ CAS 号 ]:
129198-88-5

[ 中文名 ]:
LYS-LYS-ALA-LEU-ARG-ARG-GLN-GLU-THR-VAL-ASP-ALA-LEU: KKALRRQETVDAL

[ 英文名 ]:
Autocamtide-2

[英文别名 ]:

autocamtide-2
Autocamtide 2

Autocamtide 2生物活性

[ 描述 ]:

Autocamtide 2是钙/钙调蛋白依赖的蛋白激酶II (CaMKII)的高选择性肽底物。它可以用于测定CaMKII的活力。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 蛋白激酶

研究领域 >> 神经疾病

多肽产品

[体外研究]

Ca /钙调蛋白依赖性蛋白激酶(CaMK)是多功能丝氨酸/苏氨酸激酶,其活性通过Ca 2+信号传导调节。它以其在学习和记忆中的关键作用而闻名。最近的研究表明,高水平的不同CaMK同种型,特别是对于CaMKII,在几种癌症中表达,例如肺癌,乳腺癌,前列腺癌和结肠癌。 CaMKII磷酸化近40种不同的蛋白质,包括酶,离子通道,激酶和转录因子,并在调节各种癌细胞的增殖,分化和存活中起关键作用[1]。

[参考文献]

[1]. Wang YY, et al. The emerging role of CaMKII in cancer. Oncotarget. 2015 May 20;6(14):11725-34.

[相关活性小分子]

Autocamtide 2物理化学性质

[ 分子式 ]:
C₆₅H₁₁₈N₂₂O₂₀

[ 分子量 ]:
1527.77000

[ 精确质量 ]:
1526.89000

[ PSA ]:
726.28000

[ LogP ]:
2.64810

[ 外观性状 ]:
白色粉末

Autocamtide 2安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

Autocamtide 2文献

Expression of a multifunctional Ca2+/calmodulin-dependent protein kinase and mutational analysis of its autoregulation.

Neuron 3 , 59, (1989)

Autophosphorylation of multifunctional Ca2+/calmodulin-dependent protein kinase converts it from a Ca2(+)-dependent to a Ca2(+)-independent or autonomous kinase, a process that may underlie some long-...

Stabilization of calmodulin-dependent protein kinase II through the autoinhibitory domain.

Biol. Chem. 270 , 2163, (1995)

The active 30-kDa chymotryptic fragment of calmodulin-dependent protein kinase II (CaM kinase II), devoid of the autoinhibitory domain, and the enzyme, autothiophosphorylated at Thr286/Thr287, were mu...

Ca2+/calmodulin-dependent protein kinase II delta2 regulates gene expression of insulin in INS-1 rat insulinoma cells.

Am. J. Physiol. 274 , 708, (1998)

Ca(2+)/calmodulin-dependent protein kinase II is a member of a broad family of ubiquitously expressed Ca(2+) sensing serine/threonine-kinases. Ca(2+)/calmodulin-dependent protein kinase II is highly e...

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