Autocamtide 2结构式
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常用名 | Autocamtide 2 | 英文名 | Autocamtide-2 |
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CAS号 | 129198-88-5 | 分子量 | 1527.77000 | |
密度 | N/A | 沸点 | N/A | |
分子式 | C65H118N22O20 | 熔点 | N/A | |
MSDS | 中文版 美版 | 闪点 | N/A |
Autocamtide 2用途Autocamtide 2是钙/钙调蛋白依赖的蛋白激酶II (CaMKII)的高选择性肽底物。 它可以用于测定CaMKII的活力。 |
中文名 | LYS-LYS-ALA-LEU-ARG-ARG-GLN-GLU-THR-VAL-ASP-ALA-LEU: KKALRRQETVDAL |
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英文名 | Autocamtide 2 trifluoroacetate salt |
英文别名 | 更多 |
描述 | Autocamtide 2是钙/钙调蛋白依赖的蛋白激酶II (CaMKII)的高选择性肽底物。 它可以用于测定CaMKII的活力。 |
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相关类别 | |
体外研究 | Ca /钙调蛋白依赖性蛋白激酶(CaMK)是多功能丝氨酸/苏氨酸激酶,其活性通过Ca 2+信号传导调节。它以其在学习和记忆中的关键作用而闻名。最近的研究表明,高水平的不同CaMK同种型,特别是对于CaMKII,在几种癌症中表达,例如肺癌,乳腺癌,前列腺癌和结肠癌。 CaMKII磷酸化近40种不同的蛋白质,包括酶,离子通道,激酶和转录因子,并在调节各种癌细胞的增殖,分化和存活中起关键作用[1]。 |
参考文献 |
[1]. Wang YY, et al. The emerging role of CaMKII in cancer. Oncotarget. 2015 May 20;6(14):11725-34. |
分子式 | C65H118N22O20 |
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分子量 | 1527.77000 |
精确质量 | 1526.89000 |
PSA | 726.28000 |
LogP | 2.64810 |
外观性状 | 白色粉末 |
个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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危险品运输编码 | NONH for all modes of transport |
Expression of a multifunctional Ca2+/calmodulin-dependent protein kinase and mutational analysis of its autoregulation.
Neuron 3 , 59, (1989) Autophosphorylation of multifunctional Ca2+/calmodulin-dependent protein kinase converts it from a Ca2(+)-dependent to a Ca2(+)-independent or autonomous kinase, a process that may underlie some long-... |
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Stabilization of calmodulin-dependent protein kinase II through the autoinhibitory domain.
Biol. Chem. 270 , 2163, (1995) The active 30-kDa chymotryptic fragment of calmodulin-dependent protein kinase II (CaM kinase II), devoid of the autoinhibitory domain, and the enzyme, autothiophosphorylated at Thr286/Thr287, were mu... |
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Ca2+/calmodulin-dependent protein kinase II delta2 regulates gene expression of insulin in INS-1 rat insulinoma cells.
Am. J. Physiol. 274 , 708, (1998) Ca(2+)/calmodulin-dependent protein kinase II is a member of a broad family of ubiquitously expressed Ca(2+) sensing serine/threonine-kinases. Ca(2+)/calmodulin-dependent protein kinase II is highly e... |
autocamtide-2 |
Autocamtide 2 |