孕烷醇酮

孕烷醇酮用途

Pregnanolone, also known as 3a5b-Pregnanolone; Kabi-2213, SKF 6455, Eltanolone, is a cell membrane modulator potentially for the treatment of pain. Pregnanolone is an endogenous neurosteroid that is biosynthesized from progesterone. It is a positive allosteric modulator of the GABAA receptor, as well as a negative allosteric modulator of the glycine receptor, and is known to have sedative, anxiolytic, anesthetic, and anticonvulsant effects. It was investigated for clinical use as a general anesthetic, but produced unwanted side effects such as convulsions on occasion, and for that reason was never marketed.

孕烷醇酮名称

[ CAS 号 ]:
128-20-1

[ 中文名 ]:
孕烷醇酮

[ 英文名 ]:
Pregnanolone

[中文别名 ]:

[英文别名 ]:

MFCD00067137
Pregnanolone II
5-Pregnan-3-ol-20-one
pregnanalone
Pregnan-20-one, 3-hydroxy-, (3α)-
PREGNAN-3A-OL-20-ONE
3alpha-hydroxy-5beta-pregnan-20-one
(3α)-3-Hydroxypregnan-20-one
Pregnan-20-one,3-hydroxy-, (3a,5b)-
Butabindide oxalate

孕烷醇酮物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
431.2±18.0 °C at 760 mmHg

[ 熔点 ]:
149ºC

[ 分子式 ]:
C₂₁H₃₄O₂

[ 分子量 ]:
318.493

[ 闪点 ]:
183.9±13.8 °C

[ 精确质量 ]:
318.255890

[ PSA ]:
37.30000

[ LogP ]:
4.89

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±2.3 mmHg at 25°C

[ 折射率 ]:
1.524

[ 储存条件 ]:
室温

孕烷醇酮MSDS

详细MSDS(安全技术说明书)

孕烷醇酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4384000

CHEMICAL NAME :: 5-beta-Pregnan-20-one, 3-alpha-hydroxy-

CAS REGISTRY NUMBER :: 128-20-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H34-O2

MOLECULAR WEIGHT :: 318.55

WISWESSER LINE NOTATION :: L E5 B666TJ A1 E1 FV1 OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,117,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 66 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,117,1968

孕烷醇酮安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H351

[ 警示性声明 ]:
P281

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R40

[ 安全声明 (欧洲) ]:
22-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
TU4384000

孕烷醇酮合成路线

详细合成路线

孕烷醇酮上下游产品

孕烷醇酮上游产品

孕烷醇酮下游产品

孕烷醇酮文献

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