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震颤真菌毒素

震颤真菌毒素用途

Verruculogen 是一种主要由青霉和曲霉属产生的毒素,在受感染的动物中引起严重震颤。Verruculogen 抑制 Ca2+ 激活的 K+ 通道。Verruculogen 是哺乳动物细胞周期的 M 期抑制剂。

震颤真菌毒素名称

[ CAS 号 ]:
12771-72-1

[ 中文名 ]:
疣孢青霉原

[ 英文名 ]:
Verruculogen

[中文别名 ]:

震颤真菌毒素

[英文别名 ]:

Verruculogen
VERRUCULOGEN FROM PENICILLIUM VERRUCULOS
VERRUCOLOGEN
tr1
Verruculogenresearch grade
TR-1TOXIN

震颤真菌毒素生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Luciane M. Kawashima, et al. The development of an analytical method for two mycotoxins, patulin and verruculogen, and survey of their presence in commercial tomato pulp. Brazilian Journal of Microbiology

[2]. Knaus HG, et al. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry. 1994 May 17;33(19):5819-28.

[3]. Cui CB, et al. Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. II. Physico-chemical properties and structures. J Antibiot (Tokyo). 1996 Jun;49(6):534-40.

震颤真菌毒素物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
738.4±60.0 °C at 760 mmHg

[ 熔点 ]:
233ºC

[ 分子式 ]:
C₂₀H₂₄BrN₃O₄

[ 分子量 ]:
511.567

[ 闪点 ]:
400.3±32.9 °C

[ 精确质量 ]:
511.231842

[ PSA ]:
112.01000

[ LogP ]:
2.60

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±2.6 mmHg at 25°C

[ 折射率 ]:
1.691

[ 储存条件 ]:
2-8°C

震颤真菌毒素MSDS

详细MSDS(安全技术说明书)

震颤真菌毒素安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302 + H312 + H332-H319

[ 警示性声明 ]:
P210-P280-P305 + P351 + P338

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R23/24/25

[ 安全声明 (欧洲) ]:
36/37/39-45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
JH4920000

[ 海关编码 ]:
38220090

震颤真菌毒素上下游产品

震颤真菌毒素上游产品

震颤真菌毒素下游产品

震颤真菌毒素文献

Verruculogen production in airborne and clinical isolates of Aspergillus fumigatus Fres.

Acta. Pharm. 55(4) , 357-64, (2005)

Among airborne aspergilli sampled in outdoor air of the Zagreb area (2002/2003), Aspergillus niger (v. Teigh.) and A. fumigatus (Fres.) were the most abundant species (20-30%), with low mean annual co...

Actions of tremorgenic fungal toxins on neurotransmitter release.

J. Neurochem. 34(1) , 33-42, (1980)

The neurochemical effects of the tremorgenic mycotoxins Verruculogen and Penitrem A, which produce a neurotoxic syndrome characterised by sustained tremors, were studied using sheep and rat synaptosom...

A comparative study of sheep and pigs given the tremorgenic mycotoxins verruculogen and penitrem A.

Res. Vet. Sci. 33(2) , 183-7, (1982)

The moulds Penicillium simplicissimum and P crustosum and the tremorgenic mycotoxins, verruculogen and penitrem A, isolated from them, were given to sheep and pigs to compare their potencies. Pigs wer...

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