没食子酸丙酯
没食子酸丙酯用途
没食子酸丙酯名称
[ CAS 号 ]:
121-79-9
[ 中文名 ]:
没食子酸丙酯
[ 英文名 ]:
Propyl Gallate
[中文别名 ]:
[英文别名 ]:
- nipa49
- Propyl 3,4,5-trihydroxybenzoate
- Propyl gallate
- 3,4,5-Trihydroxybenzoic acid propyl ester
- gallic acid propyl ester
- Benzoic acid, 3,4,5-trihydroxy-, propyl ester
- Sustane PG
- Gallic acid n-propyl ester
- tenoxpg
- MFCD00002196
没食子酸丙酯生物活性
[ 描述 ]:
[ 相关类别 ]:
[参考文献]
没食子酸丙酯物理化学性质
[ 密度 ]:
1.4±0.1 g/cm3
[ 沸点 ]:
448.6±40.0 °C at 760 mmHg
[ 熔点 ]:
146-149 °C(lit.)
[ 分子式 ]:
C10H12O5
[ 分子量 ]:
212.199
[ 闪点 ]:
181.3±20.8 °C
[ 精确质量 ]:
212.068466
[ PSA ]:
86.99000
[ LogP ]:
2.60
[ 外观性状 ]:
白色粒状的
[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C
[ 折射率 ]:
1.596
[ 储存条件 ]:
0-6°C
[ 水溶解性 ]:
0.35 g/100 mL (25 ºC)
没食子酸丙酯MSDS
没食子酸丙酯毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LW8400000
- CHEMICAL NAME :
- Gallic acid, propyl ester
- CAS REGISTRY NUMBER :
- 121-79-9
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 27
- MOLECULAR FORMULA :
- C10-H12-O5
- MOLECULAR WEIGHT :
- 212.22
- WISWESSER LINE NOTATION :
- QR BQ CQ EVO3
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 380 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1700 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2750 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 2480 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 42 gm/kg/14D-C
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 700 mg/kg/7D-I
- TOXIC EFFECTS :
- Liver - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 113750 mg/kg/13W-C
- TOXIC EFFECTS :
- Gastrointestinal - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 84 gm/kg/14D-C
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 168 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 45 gm/kg
- SEX/DURATION :
- female 1-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 19 gm/kg
- SEX/DURATION :
- female 1-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2500 mg/kg
- SEX/DURATION :
- female 1-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 5 mg/L
- REFERENCE :
- SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 236,933,1987 *** REVIEWS *** TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),23,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82907 No. of Facilities: 1188 (estimated) No. of Industries: 6 No. of Occupations: 8 No. of Employees: 5592 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82907 No. of Facilities: 1806 (estimated) No. of Industries: 18 No. of Occupations: 29 No. of Employees: 42475 (estimated) No. of Female Employees: 23494 (estimated)
没食子酸丙酯安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302-H317
[ 警示性声明 ]:
P280-P301 + P312 + P330
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ 危害码 (欧洲) ]:
Xn:Harmful
[ 风险声明 (欧洲) ]:
R22;R43
[ 安全声明 (欧洲) ]:
S24-S37
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
2
[ RTECS号 ]:
LW8400000
[ 海关编码 ]:
29182950
没食子酸丙酯合成路线
没食子酸丙酯上下游产品
没食子酸丙酯上游产品
没食子酸丙酯下游产品
没食子酸丙酯制备
五倍子中含有50%~70%的单宁,单宁经酶鹪或水解可得没食子酸。
(1)发酵法 将风干的五倍子破碎至0.5~1.0cm,筛去含虫粉,用4倍的水于40~60℃下浸提18h;采用逆循环法共浸提4次,使最终浸提液达相对密度1.058;浸提液在50~60℃下用5%的活性炭保温搅拌脱色4h;趁热过滤,滤渣用水洗涤4次。合并滤液和洗液,于60℃下减压浓缩,得到30%~35%的单宁溶液;将其冷至室温后接入总液量2%的黑曲霉种子,在30℃左右发酵8~9d,以清水洗涤沉淀物得粗没食子酸,再重结晶即得成品。
(2)水解法 将280kg 95%的硫酸加入1670kg 20%的单宁溶液,在105℃下搅拌水解6h,或将150kg 95%的硫酸加入1670kg 20%的单宁溶液,在133~135℃和0.18~0.20MPa下搅拌反应2h。反应物冷却至10℃:析出结晶,分离得粗品;再将其溶解于70~80℃的水中,加入总液量5%的活性炭,保温搅拌10min,趁热过滤;滤液冷却至室温,静置12h,结晶、分离得第一次脱色精品;将其用同样的方法重结晶一次得第二次脱色精品,经干燥可得200kg的成品。
2. PG的合成
在带分水装置的烧瓶中加入0.1mol没食子酸、0.3mol丙醇、20mL苯或60~80℃石油醚和0.01~0.04mol对甲苯磺酸,加热回流至无明显水分出时止;把反应混合物(呈浅紫红色)先常压后减压蒸出过量的丙醇和带水剂;在不断的搅拌下,趁热将剩余物倒入冷水中,抽滤后先后用稀碱液和水洗至中性,再脱色、用水重结晶,并于80℃烘干得熔点147~148"C的白色针状结晶,收率87.2%~89.5%。
用70%的高氯酸代替对甲苯磺酸,收率88.1%~88.6%。
没食子酸丙酯海关
[ 海关编码 ]: 2918290000
[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单
[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验
[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%
没食子酸丙酯文献
J. Virol. 89(6) , 3396-411, (2015)
In kidney transplant patients with BK polyomavirus (BKPyV) nephropathy, viral variants arise bearing rearranged noncoding control regions (rr-NCCRs) that increase viral early gene expression, replicat...
HIV-1 and its gp120 inhibits the influenza A(H1N1)pdm09 life cycle in an IFITM3-dependent fashion.PLoS ONE 9(6) , e101056, (2014)
HIV-1-infected patients co-infected with A(H1N1)pdm09 surprisingly presented benign clinical outcome. The knowledge that HIV-1 changes the host homeostatic equilibrium, which may favor the patient res...
Diminished viral control during simian immunodeficiency virus infection is associated with aberrant PD-1hi CD4 T cell enrichment in the lymphoid follicles of the rectal mucosa.J. Immunol. 193(9) , 4527-36, (2014)
The inhibitory receptor programmed death-1 (PD-1) has been shown to regulate CD8 T cell function during chronic SIV infection; however, its role on CD4 T cells, specifically in the gut-associated lymp...
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公司名:上海吉至生化科技有限公司
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价格:
¥148.0/20mg
¥218.0/500g
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区域:上海市嘉定区
价格:
¥1540.0/250g
¥622.0/100g
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产品详情:Propyl Gallate
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
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¥180.9/500mg
¥205.9/1ml
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标题:没食子酸丙酯_MSDS_用途_密度_没食子酸丙酯CAS号【121-79-9】_化源网 地址:https://www.chemsrc.com/amp/cas/121-79-9_80247.html