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(±)-石杉碱甲

(±)-石杉碱甲用途

Huperzine A是传统中草药中提取的活性石松属生物碱,是可逆的乙酰胆碱酯酶(ACE)抑制剂,在中国被广泛的运用于阿尔茨海默病。

(±)-石杉碱甲名称

[ CAS 号 ]:
120786-18-7

[ 中文名 ]:
石杉碱甲

[ 英文名 ]:
Huperzine A

[英文别名 ]:

(+-)-HUPERZINE A
HUPERZINE A (+/-)-
MFCD00171439
(±)-Huperzine A
(+/-)-HUPERZINE A
(+/-)-Huperazine A
Huperzine A

(±)-石杉碱甲生物活性

[ 描述 ]:

Huperzine A是传统中草药中提取的活性石松属生物碱,是可逆的乙酰胆碱酯酶(ACE)抑制剂,在中国被广泛的运用于阿尔茨海默病。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 疼痛

天然产物 >> 生物碱

研究领域 >> 神经疾病

[参考文献]

[1]. Burshtein G, Friedman M, Greenberg S, Hoffman A. Transepithelial Transport of a Natural Cholinesterase Inhibitor, Huperzine A, along the Gastrointestinal Tract: the Role of Ionization on Absorption Mechanism. Planta Med. 2013 Jan 23.

[2]. Ruan Q, Liu F, Gao Z, et al. The anti-inflamm-aging and hepatoprotective effects of huperzine A in d-galactose-treated rats. Mech Ageing Dev. 2013 Jan 8. pii: S0047-6374(12)00182-0.

[3]. Zhang HY. New insights into huperzine A for the treatment of Alzheimer's disease. Acta Pharmacol Sin. 2012 Sep;33(9):1170-5.

[4]. Wang J, Zhang HY, Tang XC. Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion. J Neurosci Res. 2010 Mar;88(4):807-15. doi: 10.1002/jnr.22237.

[5]. Park P, Schachter S, Yaksh T. Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats. Neurosci Lett. 2010 Feb 5;470(1):6-9. doi: 10.1016/j.neulet.2009.12.033.

[相关活性小分子]

(±)-石杉碱甲物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
505.0±50.0 °C at 760 mmHg

[ 分子式 ]:
C₁₅H₁₈N₂O

[ 分子量 ]:
242.316

[ 闪点 ]:
259.2±30.1 °C

[ 精确质量 ]:
242.141907

[ PSA ]:
58.88000

[ LogP ]:
0.71

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.626

[ 储存条件 ]:
2-8°C

(±)-石杉碱甲安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311 + H331-H315-H319-H335

[ 警示性声明 ]:
P261-P280-P301 + P310-P305 + P351 + P338-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
23/24/25-36/37/38

[ 安全声明 (欧洲) ]:
26-36/37/39-45

[ 危险品运输编码 ]:
UN 1544 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
PB9185700

(±)-石杉碱甲制备

石杉科石杉属植物蛇足石杉的茎叶。

(±)-石杉碱甲文献

Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat.

J. Neurosci. Res. 24 , 276, (1989)

The present study represents the first comprehensive investigation of the effect of huperzine A (HUP-A), a new cholinesterase inhibitor (ChEI) isolated from a Lycopodium species, upon acetylcholineste...

Effect of triterpenoid saponins from Bacopa monniera on scopolamine-induced memory impairment in mice.

Planta Med. 75 , 568-74, (2009)

Three new saponins, bacopasides IX-XI (1- 3), together with their known analogues bacopaside I (4), bacopaside II (5), bacopasaponsin C (6), and bacopasaponsin D (7), were isolated from the whole plan...

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