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P-乙酰氨基苯-B-D-葡萄糖酸钠盐

P-乙酰氨基苯-B-D-葡萄糖酸钠盐用途

Acetaminophen glucuronide 是一种安全有效的解热镇痛剂。Acetaminophen glucuronide对肝脏和肾脏具有潜在毒性。

P-乙酰氨基苯-B-D-葡萄糖酸钠盐名称

[ CAS 号 ]:
120595-80-4

[ 中文名 ]:
P-乙酰氨基苯-B-D-葡萄糖酸钠盐

[ 英文名 ]:
acetaminophen glucuronide sodium salt

[中文别名 ]:

[英文别名 ]:

MFCD00153898
ACETAMINOPHEN GLUCURONIDE SODIUM SALT
Acetaminophen glucuronide,Paracetamol glucuronide
Acetaminophen glucuronide Paracetamol glucuronide

P-乙酰氨基苯-B-D-葡萄糖酸钠盐生物活性

[ 描述 ]:

Acetaminophen glucuronide 是一种安全有效的解热镇痛剂。Acetaminophen glucuronide对肝脏和肾脏具有潜在毒性。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

[参考文献]

[1]. MazaleuskayaLL, et al. PharmGKB summary: pathways of acetaminophen metabolism at thetherapeutic versus toxic doses. Pharmacogenet Genomics. 2015 Aug;25(8):416-26.

P-乙酰氨基苯-B-D-葡萄糖酸钠盐物理化学性质

[ 熔点 ]:
232-233ºC (dec)

[ 分子式 ]:
C₁₄H₁₆NNaO₈

[ 分子量 ]:
349.27

[ 精确质量 ]:
349.07700

[ PSA ]:
148.38000

[ 外观性状 ]:
灰白色水晶般的固体

[ 储存条件 ]:
−20°C

P-乙酰氨基苯-B-D-葡萄糖酸钠盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

P-乙酰氨基苯-B-D-葡萄糖酸钠盐合成路线

详细合成路线

P-乙酰氨基苯-B-D-葡萄糖酸钠盐上下游产品

P-乙酰氨基苯-B-D-葡萄糖酸钠盐上游产品

P-乙酰氨基苯-B-D-葡萄糖酸钠盐下游产品

P-乙酰氨基苯-B-D-葡萄糖酸钠盐文献

Transporter-mediated uptake of UDP-glucuronic acid by human liver microsomes: assay conditions, kinetics, and inhibition.

Drug Metab. Dispos. 43(1) , 147-53, (2014)

This study characterized the kinetics, variability, and factors that affect UDP-glucuronic acid (UDP-GlcUA) uptake by human liver microsomes (HLM). Biphasic kinetics were observed for UDP-GlcUA uptake...

Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater.

J. Pharm. Biomed. Anal. 106 , 61-70, (2015)

An analytical methodology for the simultaneous determination of seven pharmaceuticals and two metabolites belonging to the non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics therapeutic gro...

The effect of sunitinib on the plasma exposure of intravenous paracetamol and its major metabolite: paracetamol glucuronide.

Eur. J. Drug Metab. Pharmacokinet. 40 , 163-70, (2015)

The study aimed to examine the effect of sunitinib on the plasma exposure of intravenous paracetamol and its major metabolite, paracetamol glucuronide. Both drugs share metabolic pathways in the liver...

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