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尿酸钠

尿酸钠用途

尿酸钠是氧自由基的清除剂,是一种非常重要的抗氧化剂,有助于维持血压的稳定和抗氧化应激。尿酸钠可以去除活性氧物种(ROS),如单线态氧和过氧亚硝酸盐,抑制脂质过氧化[1][2]。

尿酸钠名称

[ CAS 号 ]:
1198-77-2

[ 中文名 ]:
尿酸二氢钠

[ 英文名 ]:
Sodium Urate

[中文别名 ]:

[英文别名 ]:

Harnsaeure,Natrium-Salz
uric acid,sodium-salt
uric
SODIUM ACID URATE SODIUM SALT
SODIUM ACID URATE
MFCD00067310
uricacidsodium
URIC ACID MONOSODIUM SALT
Uric acid, monosodium salt
Monosodium Urate

尿酸钠生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

尿酸(400μM；48小时)保护Caco-2细胞免受吲哚美辛诱导的脂质过氧化[2]。用吲哚美辛和尿酸(200μmIND加400μmUA)联合处理细胞；与单独使用消炎痛培养的细胞相比,24小时)显著降低ROS水平。用吲哚美辛和尿酸(200μmIND加400μmUA)处理的Caco-2细胞的细胞活力；24小时)比单独使用吲哚美辛处理的细胞中的浓度高。尿酸通过其抗氧化活性对吲哚美辛诱导的肠细胞变化具有保护作用[2]。

[体内研究]

尿酸(250mg/kg；p、改善消炎痛引起的肠病[2]。在消炎痛诱导的肠病小鼠模型中,口服尿酸可减少回肠中ROS的积累[2]。动物模型：8周龄雄性C57BL/6J小鼠[2]剂量：250mg/kg体重给药：P.o.结果：当服用消炎痛的小鼠同时口服尿酸时,溃疡面积显著减少,呈尿酸剂量依赖性。

[参考文献]

[1]. Yasutake Y, et al. Uric acid ameliorates indomethacin-induced enteropathy in mice through its antioxidant activity. J Gastroenterol Hepatol. 2017;32(11):1839-1845.

[2]. Wang Q, et al. Recent Progress on Uric Acid Detection: A Review. Crit Rev Anal Chem. 2020;50(4):359-375.

尿酸钠物理化学性质

[ 分子式 ]:
C₅H₃N₄NaO₃

[ 分子量 ]:
190.092

[ 精确质量 ]:
190.010284

[ PSA ]:
117.46000

[ 外观性状 ]:
白色至白色带有黄色粉末

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable.

尿酸钠MSDS

详细MSDS(安全技术说明书)

尿酸钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YU7062000

CHEMICAL NAME :: Uric acid, monosodium salt

CAS REGISTRY NUMBER :: 1198-77-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C5-H3-N4-O3.Na

MOLECULAR WEIGHT :: 190.11

WISWESSER LINE NOTATION :: T56 BMVM FMVMVJ &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 300 mg/kg

SEX/DURATION :: female 8-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 6,289,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7188 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1358 (estimated) No. of Female Employees: 956 (estimated)

尿酸钠安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YU7062000

[ 海关编码 ]:
2933990090

尿酸钠海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

尿酸钠文献

Molecular Mechanisms Underlying Urate-Induced Enhancement of Kv1.5 Channel Expression in HL-1 Atrial Myocytes.

Circ. J. 79 , 2659-68, (2015)

Hyperuricemia induces endothelial dysfunction, oxidative stress and inflammation, increasing cardiovascular morbidities. It also raises the incidence of atrial fibrillation; however, underlying mechan...

Direct radical scavenging activity of benzbromarone provides beneficial antioxidant properties for hyperuricemia treatment.

Biol. Pharm. Bull. 38(3) , 487-92, (2015)

Uric acid exerts an important antioxidant effect against external oxidative stress under physiological conditions. However, uric acid itself can increase oxidative stress via reduced nicotinamide aden...

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尿酸钠