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4-氨基-7-氯喹啉

4-氨基-7-氯喹啉名称

[ CAS 号 ]:
1198-40-9

[ 中文名 ]:
4-氨基-7-氯喹啉

[ 英文名 ]:
7-Chloro-4-quinolinamine

[英文别名 ]:

7-chloroquinolin-4-amine
4-Amino-7-chloroquinoline
4-Quinolinamine, 7-chloro-
7-Chloro-4-quinolinamine
7-chloro-quinolin-4-ylamine
7-chloro-4-aminoquinoline
MFCD00828822

4-氨基-7-氯喹啉物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
366.8±27.0 °C at 760 mmHg

[ 熔点 ]:
96-97°C

[ 分子式 ]:
C₉H₇ClN₂

[ 分子量 ]:
178.618

[ 闪点 ]:
175.7±23.7 °C

[ 精确质量 ]:
178.029770

[ PSA ]:
38.91000

[ LogP ]:
2.38

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.712

[ 储存条件 ]:
2-8℃，避光，惰性气体保存

[ 水溶解性 ]:
REACTS

4-氨基-7-氯喹啉MSDS

4-氨基-7-氯喹啉安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H319

[ 警示性声明 ]:
P301 + P310-P305 + P351 + P338

[ 危害码 (欧洲) ]:
C

[ 风险声明 (欧洲) ]:
R34:Causes burns. R40:Limited evidence of a carcinogenic effect. R14:Reacts violently with water.

[ 安全声明 (欧洲) ]:
S23-S24/25-S26-S36/37/39-S45-S22

[ 危险品运输编码 ]:
UN 3265 8/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
RR4584700

[ 包装等级 ]:
II

[ 危险类别 ]:
4.1

[ 海关编码 ]:
29420000

4-氨基-7-氯喹啉合成路线

4-氨基-7-氯喹啉上下游产品

4-氨基-7-氯喹啉上游产品

4-氨基-7-氯喹啉下游产品

4-氨基-7-氯喹啉海关

[ 海关编码 ]: 2933499090

[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-氨基-7-氯喹啉文献

Overcoming drug resistance to heme-targeted antimalarials by systematic side chain variation of 7-chloro-4-aminoquinolines.

J. Med. Chem. 51(7) , 1995-8, (2008)

Systematic variation of the branching and basicity of the side chain of chloroquine yielded a series of new 7-chloro-4-aminoquinoline derivatives exhibiting high in vitro activity against four differe...

New chimeric antimalarials with 4-aminoquinoline moiety linked to a tetraoxane skeleton.

J. Med. Chem. 51(19) , 6216-9, (2008)

The synthesis of the chimeric molecules consisting of two pharmacophores, tetraoxane and 7-chloro-4-aminoquinoline, is reported. The tetraoxanes 2, 4, and 8 show relatively potent in vitro antimalaria...

An ELISA test for detecting chloroquine in urine.

Trans. R. Soc. Trop. Med. Hyg. 82(2) , 216-20, (1988)

Two ELISA tests for detecting chloroquine in urine have been developed using polyclonal and monoclonal antibodies which react with the 7-chloro-4-amino-quinoline part of the chloroquine molecule and t...

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