BiCAPPA

BiCAPPA用途

BiCAPPA是第一个二价反离子配体。BiCAPPA可以降低羊瘙痒病感染细胞中朊病毒蛋白(PrPSc)的感染构象形式,EC50为0.32μM[1][2]。

BiCAPPA名称

[ CAS 号 ]:
119662-55-4

[ 英文名 ]:
BiCAPPA

[英文别名 ]:

BiCAPPA

BiCAPPA生物活性

[ 描述 ]:

BiCAPPA是第一个二价反离子配体。BiCAPPA可以降低羊瘙痒病感染细胞中朊病毒蛋白(PrPSc)的感染构象形式,EC50为0.32μM[1][2]。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

[体外研究]

双CAPPA(10 nM-2μM；5天)降低感染痒病的小鼠下丘脑细胞的蛋白酶 K抗性 PrPSc,EC50值为 0.32μM[2]

[参考文献]

[1]. Uliassi E, et, al. 10-Medicinal Chemistry of Hybrids for Neurodegenerative Diseases. Design of Hybrid Molecules for Drug Development. 2017, Pages 259-277.

[2]. Bongarzone S, et, al. Parallel synthesis, evaluation, and preliminary structure-activity relationship of 2,5-diamino-1,4-benzoquinones as a novel class of bivalent anti-prion compound. J Med Chem. 2010 Nov 25;53(22):8197-201.

BiCAPPA物理化学性质

[ 分子式 ]:
C₃₈H₄₀Cl₂N₆O₂

[ 分子量 ]:
683.66900

[ 精确质量 ]:
682.25900

[ PSA ]:
81.24000

[ LogP ]:
7.05480

BiCAPPAMSDS

详细MSDS(安全技术说明书)

BiCAPPA安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

BiCAPPA文献

Protein aggregation and neurodegenerative disease.

Nat. Med. 10 Suppl , S10-S17 , (2004)

Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion diseases are increasingly being realized...

Potent inhibition of scrapie prion replication in cultured cells by bis-acridines.

Proc. Natl. Acad. Sci. U. S. A. 100 , 3416-3421, (2003)

Prion diseases are characterized by an accumulation of PrP(Sc), a misfolded isoform of the normal cellular prion protein, PrP(C). We previously reported the bioactivity of acridine-based compounds aga...

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