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泛影酸

泛影酸用途

Diatrizoic acid 是一种碘化放射造影剂。

泛影酸名称

[ CAS 号 ]:
117-96-4

[ 中文名 ]:
泛影酸

[ 英文名 ]:
Diatrizoic acid

[中文别名 ]:

[英文别名 ]:

Amidotrizoic Acid,Diatrizoic acid
3,5-bis(acetylamino)-2,4,6-triiodobenzoic acid
3,5-Di(acetamido)-2,4,6-triiodobenzoic Acid
EINECS 204-223-6
3,5-diacetamido-2,4,6-triiodo-benzoic acid
Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-
MFCD00069960
Amidotrizoic Acid
Urografin
2,4,6-Triiodo-3,5-diacetamidobenzoic acid

泛影酸生物活性

[ 描述 ]:

Diatrizoic acid 是一种碘化放射造影剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[体内研究]

泛影酸是碘化放射性对比剂。在吹入泛影酸纳米颗粒附聚物后,大鼠肺组织的组织学检查显示没有急性毒性或炎症。泛影酸纳米粒子附聚物提供了一种有前途的放射性对比剂,用于安全有效的肺部可视化[1]。

[动物实验]

雌性Sprague-Dawley大鼠（200至250克）饲养在温度和湿度受控的房间中，可自由获取食物和水，并保持12小时光照/黑暗循环。用67.5mg / kg氯胺酮，3.5mg / kg甲苯噻嗪和0.66mg / kg乙酰丙嗪皮下混合物麻醉大鼠。在麻醉下，将大鼠置于加热垫上以维持体温37℃。使用干粉吹入器通过气管内吹气给予泛影酸纳米颗粒附聚物（10mg）。在实验结束时，通过过量吸入异氟醚，然后收获主要器官使大鼠安乐死[1]。

[参考文献]

[1]. El-Gendy N, et al. Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent. Int J Pharm. 2010 May 31;391(1-2):305-12.

[相关活性小分子]

泛影酸物理化学性质

[ 密度 ]:
2.7±0.1 g/cm3

[ 沸点 ]:
720.2±70.0 °C at 760 mmHg

[ 熔点 ]:
>300ºC

[ 分子式 ]:
C₁₁H₉I₃N₂O₄

[ 分子量 ]:
613.914

[ 闪点 ]:
389.4±35.7 °C

[ 精确质量 ]:
613.769592

[ PSA ]:
95.50000

[ LogP ]:
1.53

[ 外观性状 ]:
无色液体

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.790

[ 储存条件 ]:
Amber Vial, -20°C Freezer

[ 水溶解性 ]:
Soluble in Methanol.

泛影酸MSDS

详细MSDS(安全技术说明书)

泛影酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG5950000

CHEMICAL NAME :: Benzoic acid, 3,5-diacetamido-2,4,6-triiodo-

CAS REGISTRY NUMBER :: 117-96-4

BEILSTEIN REFERENCE NO. :: 2225144

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C11-H9-I3-N2-O4

MOLECULAR WEIGHT :: 613.92

WISWESSER LINE NOTATION :: 1VMR BI DI FI CVQ EMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >12300 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Lungs, Thorax, or Respiration - respiratory stimulation Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 19,2411,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8900 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Lungs, Thorax, or Respiration - respiratory stimulation Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 19,2411,1985

泛影酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DG5950000

[ 海关编码 ]:
2924299090

泛影酸合成路线

详细合成路线

泛影酸上下游产品

泛影酸上游产品

泛影酸下游产品

泛影酸制备

由3,5-二氨基苯甲酸经碘化、乙酰化而得。

泛影酸海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

泛影酸文献

Biodegradation of pharmaceuticals in hospital wastewater by staged Moving Bed Biofilm Reactors (MBBR).

Water Res. 83 , 293-302, (2015)

Hospital wastewater represents a significant input of pharmaceuticals into municipal wastewater. As Moving Bed Biofilm Reactors (MBBRs) appear to remove organic micro-pollutants, hospital wastewater w...

Bone metastases in castration-resistant prostate cancer: associations between morphologic CT patterns, glycolytic activity, and androgen receptor expression on PET and overall survival.

Radiology 271(1) , 220-9, (2014)

To compare the features of bone metastases at computed tomography (CT) to tracer uptake at fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) and fluorine 18 16β-fluoro-5-dihydrot...

Optimization of culture conditions for bone marrow stromal cells in RPMI-1640 medium.

Rev. Med. Chir. Soc. Med. Nat. Iasi. 116(1) , 222-7, (2012)

Bone marrow mesenchymal stem cells are important for both research and clinical purpose. A number of culture methods for these cells are available on the market, many of them consisting of specialized...

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泛影酸