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甲泛影酸

甲泛影酸用途

Metrizoic acid (Metrizoate) 是一种离子造影剂。Metrizoic acid (Metrizoate) 显示出高渗透压,有诱发过敏反应的风险。

甲泛影酸名称

[ CAS 号 ]:
1949-45-7

[ 中文名 ]:
甲泛影酸

[ 英文名 ]:
Metrizoic acid

[中文别名 ]:

[英文别名 ]:

Metrizoic acid
metrizoate
3,5-DiacetaMido-N-Methyl-2,4,6-triiodobenzoic Acid
Metrizoic
Metrizoesaeure
MFCD00867964
Triosil-280
EINECS 217-761-1

甲泛影酸生物活性

[ 描述 ]:

Metrizoic acid (Metrizoate) 是一种离子造影剂。Metrizoic acid (Metrizoate) 显示出高渗透压,有诱发过敏反应的风险。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Vik-Mo H, et al. Hemodynamic and electrocardiographic consequences of high- and low-osmolality contrast agents for left ventricular angiography. Cathet Cardiovasc Diagn. 1988;14(3):143-9.

[2]. Sortland O, et al. Iopentol in urography. A clinical comparison between iopentol and metrizoate includingdelayed reactions. Acta Radiol. 1992 Jul;33(4):368-73.

[3]. Holtås S,et al. Contrast enhanced brain CT. Comparison between iohexol and metrizoate. Neuroradiology. 1983;24(4):213-5.

甲泛影酸物理化学性质

[ 密度 ]:
2.483g/cm3

[ 沸点 ]:
678.8ºC at 760mmHg

[ 分子式 ]:
C₁₂H₁₁I₃N₂O₄

[ 分子量 ]:
627.94000

[ 闪点 ]:
364.3ºC

[ 精确质量 ]:
627.78500

[ PSA ]:
86.71000

[ LogP ]:
3.21270

[ 外观性状 ]:
白色类白色晶体-粉末

[ 蒸汽压 ]:
2.35E-19mmHg at 25°C

[ 折射率 ]:
1.77

[ 储存条件 ]:
室温，干燥

甲泛影酸MSDS

详细MSDS(安全技术说明书)

甲泛影酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG0887300

CHEMICAL NAME :: Benzoic acid, 3-acetamido-2,4,6-triiodo-5-(N-methylacetamido)-

CAS REGISTRY NUMBER :: 1949-45-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C12-H11-I3-N2-O4

MOLECULAR WEIGHT :: 627.95

WISWESSER LINE NOTATION :: 1VN1&R BI DI FI CVQ EMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 38100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 29600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >46800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 36 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 17,340,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 234 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982

甲泛影酸安全信息

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37/39

[ RTECS号 ]:
DG0887300

[ 海关编码 ]:
2924299090

甲泛影酸海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%